Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia
المؤلفون المشاركون
Mendonca, Berenice Bilharinho
Moreira, Ricardo P. P.
Gomes, Larissa G.
Madureira, Guiomar
Bachega, Tânia A. S. S.
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Pediatric CAH patients have an increased risk of cardiovascular disease, and it remains unknown if genetic predisposition is a contributing factor.
Glucocorticoid receptor gene (NR3C1) polymorphisms are associated with an adverse metabolic profile.
Our aim was to analyze the association between the NR3C1 polymorphisms and the metabolic profile of pediatric CAH patients.
Methods.
Forty-one patients (26SW/15SV) received glucocorticoid (GC) replacement therapy to achieve normal androgen levels.
Obesity was defined by BMI ≥ 95 th percentile.
NR3C1 alleles were genotyped, and association analyses with phenotype were done with Chi-square, t-test, and multivariate and regression analysis.
Results.
Obesity was observed in 31.7% of patients and was not correlated with GC doses and treatment duration.
Z-score BMI was positively correlated with blood pressure, triglycerides, LDL-c levels, and HOMA-IR.
NR3C1 polymorphisms, BclI and A3669G, were found in 23.1% and 9.7% of alleles, respectively.
A3669G carriers presented higher LDL-c levels compared to wild-type subjects.
BclI-carriers and noncarriers did not differ.
Conclusion.
Our results suggest that A3669G-polymorphism could be involved with a susceptibility to adverse lipid profile in pediatric CAH patients.
This study provides new insight into the GR screening during CAH treatment, which could help to identify the subgroup of at-risk patients who would most benefit from preventive therapeutic action.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moreira, Ricardo P. P.& Gomes, Larissa G.& Madureira, Guiomar& Mendonca, Berenice Bilharinho& Bachega, Tânia A. S. S.. 2014. Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036533
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moreira, Ricardo P. P.…[et al.]. Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036533
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moreira, Ricardo P. P.& Gomes, Larissa G.& Madureira, Guiomar& Mendonca, Berenice Bilharinho& Bachega, Tânia A. S. S.. Influence of the A3669G Glucocorticoid Receptor Gene Polymorphism on the Metabolic Profile of Pediatric Patients with Congenital Adrenal Hyperplasia. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036533
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036533
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر