Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models

المؤلفون المشاركون

Cristina, Carolina
Luque, Guillermina María
Demarchi, Gianina
Lopez Vicchi, Felicitas
Zubeldia-Brenner, Lautaro
Perez Millan, Maria Ines
Perrone, Sofia
Ornstein, Ana Maria
Lacau-Mengido, Isabel M.
Berner, Silvia Inés
Becu-Villalobos, Damasia

المصدر

International Journal of Endocrinology

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-11-18

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

The role of angiogenesis in pituitary tumor development has been questioned, as pituitary tumors have been usually found to be less vascularized than the normal pituitary tissue.

Nevertheless, a significantly higher degree of vasculature has been shown in invasive or macropituitary prolactinomas when compared to noninvasive and microprolactinomas.

Many growth factors and their receptors are involved in pituitary tumor development.

For example, VEGF, FGF-2, FGFR1, and PTTG, which give a particular vascular phenotype, are modified in human and experimental pituitary adenomas of different histotypes.

In particular, vascular endothelial growth factor, VEGF, the central mediator of angiogenesis in endocrine glands, was encountered in experimental and human pituitary tumors at different levels of expression and, in particular, was higher in dopamine agonist resistant prolactinomas.

Furthermore, several anti-VEGF techniques lowered tumor burden in human and experimental pituitary adenomas.

Therefore, even though the role of angiogenesis in pituitary adenomas is contentious, VEGF, making permeable pituitary endothelia, might contribute to adequate temporal vascular supply and mechanisms other than endothelial cell proliferation.

The study of angiogenic factor expression in aggressive prolactinomas with resistance to dopamine agonists will yield important data in the search of therapeutical alternatives.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Cristina, Carolina& Luque, Guillermina María& Demarchi, Gianina& Lopez Vicchi, Felicitas& Zubeldia-Brenner, Lautaro& Perez Millan, Maria Ines…[et al.]. 2014. Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036535

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Cristina, Carolina…[et al.]. Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models. International Journal of Endocrinology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1036535

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Cristina, Carolina& Luque, Guillermina María& Demarchi, Gianina& Lopez Vicchi, Felicitas& Zubeldia-Brenner, Lautaro& Perez Millan, Maria Ines…[et al.]. Angiogenesis in Pituitary Adenomas: Human Studies and New Mutant Mouse Models. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1036535

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1036535