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Evaluating the Efficacy of Primary Treatment for Graves’ Disease Complicated by Thyrotoxic Periodic Paralysis
المؤلفون المشاركون
Chang, Rita Yuk-Kwan
Chan, Ai Chen
Wong, Kai-Pun
Lang, Brian Hung-Hin
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of Graves’ disease (GD).
The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP.
Methods.
Sixteen patients with GD/TPP were followed over a 14-year period.
ATD was generally prescribed upfront for 12–18 months before RAI or surgery was considered.
Outcomes such as thyrotoxic or TPP relapses were compared between the three modalities.
Results.
Eight (50.0%) patients had ATD alone, 4 (25.0%) had RAI, and 4 (25.0%) had surgery as primary treatment.
Despite being able to withdraw ATD in all 8 patients for 37.5 (22–247) months, all subsequently developed thyrotoxic relapses and 4 (50.0%) had ≥1 TPP relapses.
Of the four patients who had RAI, two (50%) developed thyrotoxic relapse after 12 and 29 months, respectively, and two (50.0%) became hypothyroid.
The median required RAI dose to render hypothyroidism was 550 (350–700) MBq.
Of the 4 patients who underwent surgery, none developed relapses but all became hypothyroid.
Conclusion.
To minimize future relapses, more definitive primary treatment such as RAI or surgery is preferred over ATD alone.
If RAI is chosen over surgery, a higher dose (>550 MBq) is recommended.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Rita Yuk-Kwan& Lang, Brian Hung-Hin& Chan, Ai Chen& Wong, Kai-Pun. 2014. Evaluating the Efficacy of Primary Treatment for Graves’ Disease Complicated by Thyrotoxic Periodic Paralysis. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036628
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Rita Yuk-Kwan…[et al.]. Evaluating the Efficacy of Primary Treatment for Graves’ Disease Complicated by Thyrotoxic Periodic Paralysis. International Journal of Endocrinology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036628
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Rita Yuk-Kwan& Lang, Brian Hung-Hin& Chan, Ai Chen& Wong, Kai-Pun. Evaluating the Efficacy of Primary Treatment for Graves’ Disease Complicated by Thyrotoxic Periodic Paralysis. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036628
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036628
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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