Correlations of Vascular Architecture and Angiogenesis with Pituitary Adenoma Histotype
المؤلفون المشاركون
Yamamoto, Tetsuya
Hara, Takuma
Akutsu, Hiroyoshi
Takano, Shingo
Matsumura, Akira
المصدر
International Journal of Endocrinology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor in solid tumors.
However, its role in angiogenesis in pituitary adenoma is controversial.
Angiogenesis in solid tumors including pituitary adenoma is commonly evaluated by microvascular density (MVD).
Here, we evaluated MVD and the role of VEGF in vascular architecture in 51 pituitary adenomas (24 nonfunctioning, 13 prolactin-secreting, 10 growth hormone-secreting, 3 adrenocorticotropic hormone-secreting, and 1 thyroid-stimulating hormone-secreting).
Paraffin sections were stained with CD34 and VEGF.
MVD and vascular architecture parameters (vessel area, diameter, perimeter, and roundness) were evaluated in CD34-stained sections.
Immunohistochemistry showed 27/51 tumors (53%) were VEGF-positive.
There were no significant differences in MVD, any vascular parameter, or adenoma volume between VEGF-positive and VEGF-negative tumors.
VEGF mRNA expression was significantly higher in VEGF-positive tumors.
There were no significant correlations between VEGF mRNA expression and MVD or vascular parameters.
However, vessel diameter and perimeter were significantly larger in prolactin-secreting than nonfunctioning and growth hormone-secreting macroadenomas.
The difference in vessel diameter was observed among both VEGF-positive and all adenomas (micro- and macroadenoma).
Thus, VEGF may have limited roles in the development of vascular architecture and tumor angiogenesis in pituitary adenomas, but the differences in vessel architecture by histotype (i.e., larger vessel diameter and perimeter in prolactin-secreting adenomas) suggest the hormonal regulation of vessel architecture rather than angiogenesis
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takano, Shingo& Akutsu, Hiroyoshi& Hara, Takuma& Yamamoto, Tetsuya& Matsumura, Akira. 2014. Correlations of Vascular Architecture and Angiogenesis with Pituitary Adenoma Histotype. International Journal of Endocrinology،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1036640
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takano, Shingo…[et al.]. Correlations of Vascular Architecture and Angiogenesis with Pituitary Adenoma Histotype. International Journal of Endocrinology No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1036640
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takano, Shingo& Akutsu, Hiroyoshi& Hara, Takuma& Yamamoto, Tetsuya& Matsumura, Akira. Correlations of Vascular Architecture and Angiogenesis with Pituitary Adenoma Histotype. International Journal of Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1036640
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036640
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر