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Fructose Induced Endotoxemia in Pediatric Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Patel, Shivani S.
Jin, Ran
Willment, Andrew
Sun, Xiaoyan
Song, Ming
Mannery, Yanci O.
Kosters, Astrid
McClain, Craig J.
Vos, Miriam B.
المصدر
International Journal of Hepatology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-09-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In preclinical studies of fructose-induced NAFLD, endotoxin appears to play an important role.
We retrospectively examined samples from three pediatric cohorts (1) to investigate whether endotoxemia is associated with the presence of hepatic steatosis; (2) to evaluate postprandial endotoxin levels in response to fructose beverage in an acute 24-hour feeding challenge, and (3) to determine the change of fasting endotoxin amounts in a 4-week randomized controlled trial comparing fructose to glucose beverages in NAFLD.
We found that adolescents with hepatic steatosis had elevated endotoxin levels compared to obese controls and that the endotoxin level correlated with insulin resistance and several inflammatory cytokines.
In a 24-hour feeding study, endotoxin levels in NAFLD adolescents increased after fructose beverages (consumed with meals) as compared to healthy children.
Similarly, endotoxin was significantly increased after adolescents consumed fructose beverages for 2 weeks and remained high although not significantly at 4 weeks.
In conclusion, these data provide support for the concept of low level endotoxemia contributing to pediatric NAFLD and the possible role of fructose in this process.
Further studies are needed to determine if manipulation of the microbiome or other methods of endotoxin reduction would be useful as a therapy for pediatric NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Ran& Willment, Andrew& Patel, Shivani S.& Sun, Xiaoyan& Song, Ming& Mannery, Yanci O.…[et al.]. 2014. Fructose Induced Endotoxemia in Pediatric Nonalcoholic Fatty Liver Disease. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036708
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Ran…[et al.]. Fructose Induced Endotoxemia in Pediatric Nonalcoholic Fatty Liver Disease. International Journal of Hepatology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1036708
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Ran& Willment, Andrew& Patel, Shivani S.& Sun, Xiaoyan& Song, Ming& Mannery, Yanci O.…[et al.]. Fructose Induced Endotoxemia in Pediatric Nonalcoholic Fatty Liver Disease. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1036708
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036708
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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