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IFNL4 ss469415590 Variant Is Associated with Treatment Response in Japanese HCV Genotype 1 Infected Individuals Treated with IFN-Including Regimens
المؤلفون المشاركون
Imazeki, Fumio
Yokosuka, Osamu
Yasui, Shin
Nakamura, Masato
Chiba, Tetsuhiro
Arai, Makoto
Wu, Shuang
Jiang, Xia
Sasaki, Reina
Haga, Yuki
Ooka, Yoshihiko
Mikami, Shigeru
Nakamoto, Shingo
Miyamura, Tatsuo
Kanda, Tatsuo
المصدر
International Journal of Hepatology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-08
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
Eradication of hepatitis C virus (HCV) is still challenging even if interferon- (IFN-) free regimens with direct-acting antiviral agents (DAAs) for HCV-infected individuals are available in clinical practice.
IFNL4 is a newly described protein, associated with human antiviral defenses.
We investigated whether IFNL4 ss469415590 variant has an effect on the prediction of treatment response in HCV-infected patients treated with IFN-including regimens.
Patients and Methods.
In all, 185 patients infected with HCV genotype 1 treated with peg-IFN plus ribavirin, with or without telaprevir, were genotyped for IFNL4 ss469415590.
We retrospectively investigated whether the role of IFNL4 ss469415590 variant and other factors could predict sustained virological response (SVR) in Japanese patients infected with HCV genotype 1.
Results.
There were 65.7%, 31.5%, and 2.8% patients in the IFNL4 ss469415590 TT/TT, TT/-G, and -G/-G groups, respectively.
SVR rates were 82.1% or 49.3% in patients treated with peg-IFN plus ribavirin with or without telaprevir, respectively.
IFNL4 ss469415590 variant and HCV viral loads or IFNL4 ss469415590 variant and early virological response were better predictors of SVR in patients treated with peg-IFN plus ribavirin with or without telaprevir, respectively.
Conclusion.
In the era of DAAs, measurement of IFNL4 ss469415590 variant could help the prediction of SVR in Japanese HCV genotype 1 infected individuals treated with IFN-including regimens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miyamura, Tatsuo& Kanda, Tatsuo& Nakamoto, Shingo& Arai, Makoto& Nakamura, Masato& Wu, Shuang…[et al.]. 2014. IFNL4 ss469415590 Variant Is Associated with Treatment Response in Japanese HCV Genotype 1 Infected Individuals Treated with IFN-Including Regimens. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036709
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miyamura, Tatsuo…[et al.]. IFNL4 ss469415590 Variant Is Associated with Treatment Response in Japanese HCV Genotype 1 Infected Individuals Treated with IFN-Including Regimens. International Journal of Hepatology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1036709
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miyamura, Tatsuo& Kanda, Tatsuo& Nakamoto, Shingo& Arai, Makoto& Nakamura, Masato& Wu, Shuang…[et al.]. IFNL4 ss469415590 Variant Is Associated with Treatment Response in Japanese HCV Genotype 1 Infected Individuals Treated with IFN-Including Regimens. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1036709
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036709
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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