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Classification of Five Uremic Solutes according to Their Effects on Renal Tubular Cells
المؤلفون المشاركون
Edamatsu, Takeo
Fujieda, Ayako
Ezawa, Atsuko
Itoh, Yoshiharu
المصدر
International Journal of Nephrology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background/Aims.
Uremic solutes, which are known to be retained in patients with chronic kidney disease, are considered to have deleterious effects on disease progression.
Among these uremic solutes, indoxyl sulfate (IS) has been extensively studied, while other solutes have been studied less to state.
We conducted a comparative study to examine the similarities and differences between IS, p-cresyl sulfate (PCS), phenyl sulfate (PhS), hippuric acid (HA), and indoleacetic acid (IAA).
Methods.
We used LLC-PK1 cells to evaluate the effects of these solutes on viable cell number, cell cycle progression, and cell death.
Results.
All the solutes reduced viable cell number after 48-hour incubation.
N-Acetyl-L-cysteine inhibited this effect induced by all solutes except HA.
At the concentration that reduced the cell number to almost 50% of vehicle control, IAA induced apoptosis but not cell cycle delay, whereas other solutes induced delay in cell cycle progression with marginal impact on apoptosis.
Phosphorylation of p53 and Chk1 and expression of ATF4 and CHOP genes were detected in IS-, PCS-, and PhS-treated cells, but not in IAA-treated cells.
Conclusions.
Taken together, the adverse effects of PCS and PhS on renal tubular cells are similar to those of IS, while those of HA and IAA differ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Edamatsu, Takeo& Fujieda, Ayako& Ezawa, Atsuko& Itoh, Yoshiharu. 2014. Classification of Five Uremic Solutes according to Their Effects on Renal Tubular Cells. International Journal of Nephrology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Edamatsu, Takeo…[et al.]. Classification of Five Uremic Solutes according to Their Effects on Renal Tubular Cells. International Journal of Nephrology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1036751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Edamatsu, Takeo& Fujieda, Ayako& Ezawa, Atsuko& Itoh, Yoshiharu. Classification of Five Uremic Solutes according to Their Effects on Renal Tubular Cells. International Journal of Nephrology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1036751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1036751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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