Photophysical Properties of Pheophorbide-a Derivatives and Their Photodynamic Therapeutic Effects on a Tumor Cell Line In Vitro
المؤلفون المشاركون
Wang, Kang-Kyun
Kim, Bong-Jin
Ko, Si-Hwan
Li, Jing
Lee, Jeong-Hyun
Shin, Hee-Won
Lee, Won-Young
Lee, Chang-Hee
Jung, Seok Hoon
Kim, Yong-Rok
المصدر
International Journal of Photoenergy
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Pheophorbide-a derivatives have been reported to be potential photosensitizers for photodynamic therapy (PDT).
In this study, photophysics of pheophorbide-a derivatives (PaDs) were investigated along with their photodynamic tumoricidal effect in vitro.
PaDs were modified by changing the coil length and/or making the hydroxyl group (–OH) substitutions.
Their photophysical properties were studied by steady-state and time-resolved spectroscopic methods.
The photodynamic tumoricidal effect was evaluated in the mouse breast cancer cell line (EMT6).
Lifetime and quantum yield of fluorescence and quantum yields of triplet state and singlet oxygen were studied to determine the dynamic energy flow.
The coil length of the substituted alkyl group did not significantly affect the spectroscopic properties.
However, the substitution with the hydroxyl group increased the quantum yields of the triplet state and the singlet oxygen due to the enhanced intersystem crossing.
In order to check the application possibility as a photodynamic therapy agent, the PaDs with hydroxyl group were studied for the cellular affinity and the photodynamic tumoricidal effect of EMT6.
The results showed that the cellular affinity and the photodynamic tumoricidal effect of PaDs with the hydroxyl group depended on the coil-length of the substituted alkyl group.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Kang-Kyun& Li, Jing& Kim, Bong-Jin& Lee, Jeong-Hyun& Shin, Hee-Won& Ko, Si-Hwan…[et al.]. 2014. Photophysical Properties of Pheophorbide-a Derivatives and Their Photodynamic Therapeutic Effects on a Tumor Cell Line In Vitro. International Journal of Photoenergy،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1037344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Kang-Kyun…[et al.]. Photophysical Properties of Pheophorbide-a Derivatives and Their Photodynamic Therapeutic Effects on a Tumor Cell Line In Vitro. International Journal of Photoenergy No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1037344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Kang-Kyun& Li, Jing& Kim, Bong-Jin& Lee, Jeong-Hyun& Shin, Hee-Won& Ko, Si-Hwan…[et al.]. Photophysical Properties of Pheophorbide-a Derivatives and Their Photodynamic Therapeutic Effects on a Tumor Cell Line In Vitro. International Journal of Photoenergy. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1037344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1037344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر