Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective
المؤلفون المشاركون
Jaffe, Adam
Homaira, Nusrat
Rawlinson, William
Snelling, Thomas L.
المصدر
International Journal of Pediatrics
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-04
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Infection with respiratory syncytial virus (RSV) is one of the major causes globally of childhood respiratory morbidity and hospitalization.
Palivizumab, a humanized monoclonal antibody, has been recommended for high risk infants to prevent severe RSV-associated respiratory illness.
This recommendation is based on evidence of efficacy when used under clinical trial conditions.
However the real-world effectiveness of palivizumab outside of clinical trials among different patient populations is not well established.
We performed a systematic review focusing on postlicensure observational studies of the protective effect of palivizumab prophylaxis for reducing RSV-associated hospitalizations in infants and children at high risk of severe infection.
We searched studies published in English between 1 January 1999 and August 2013 and identified 420 articles, of which 20 met the inclusion criteria.
This review supports the recommended use of palivizumab for reducing RSV-associated hospitalization rates in premature infants born at gestational age < 33 weeks and in children with chronic lung and heart diseases.
Data are limited to allow commenting on the protective effect of palivizumab among other high risk children, including those with Down syndrome, cystic fibrosis, and haematological malignancy, indicating further research is warranted in these groups.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Homaira, Nusrat& Rawlinson, William& Snelling, Thomas L.& Jaffe, Adam. 2014. Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective. International Journal of Pediatrics،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1037486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Homaira, Nusrat…[et al.]. Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective. International Journal of Pediatrics No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1037486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Homaira, Nusrat& Rawlinson, William& Snelling, Thomas L.& Jaffe, Adam. Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective. International Journal of Pediatrics. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1037486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1037486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر