Evaluation of modified flare up versus modified long protocols for low responders how were undergoing intracytoplasmic sperm injection-embryo transfer

الملخص EN

Objective: to evaluate two COH protocols designed for poor ovarian responders undergoing ICSI.

Design: Randomized prospective study.

Setting: Assisted reproductive technology unit in International Islamic Center for Population Study and Research (IICPSR), Al-Azhar University.

Patient(s): Fifty four poor ovarian responder patients were recruited on the basis of there results in previous cycle(s).

Intervention: Modified long protocol in which a standard GnRH agonist dose was used until pituitary DR, after which the GnRH agonist dose was halved during stimulation, or modified flare protocol in which high dose of GnRH agonist was administrated for the 1st four days, followed by a standard GnRH agonist dose.

Main outcome measure(s): Number of meta two phase oocyte collected.

Results: A total of 54 infertile women with the patient's age ranged from 20 to 37 years were included in this study.

30 patients (55.5%) were stimulated with modified short protocol while 24 patients (45.5%) were stimulated with modified long protocol.

With the exception of total HMG dose (number of ampoules), there had been no significant differences in the studied characteristics among the patient stimulated with the different protocols.

There have been statistically significant differences among the patient stimulated with the different protocols with respect to number of follicles >20mm, E2HCG, and number of meta phase II oocytes (Mil) where P-value were <0.0001.

The mean number of follicles >20mm was, 5.5±1.4 in short protocol and 12.9±4.4 in long protocol.