Design and Synthesis of an Indole-Estrogen Derivative

الملخص EN

There are several methods reported for synthesis of aromatic-condensed derivatives; nevertheless, expensive reagents and special conditions are required.

Therefore, in this study, an indole-estrogen derivative (3-[4-(2-butyl-3-cyclohexylimino-4-piperidin-1-yl-cyclobutylidencarbamoyl)]-phenoxy-NH-indolo[2′,3′:17,16]estra-1,3,5(10)triene) was synthesized using some strategies.

The structure of all compounds obtained was confirmed by spectroscopic and spectrometric methods.

In conclusion, a facile procedure for the formation of an indole-estrogen derivative was developed in this study.