T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease
المؤلفون المشاركون
Grzegorzewska, Alicja E.
Ostromecki, Grzegorz
Zielińska, Paulina
Mostowska, Adrianna
Jagodziński, Paweł P.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-22
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Background.
T-cell cytokine gene polymorphisms and vitamin D pathway gene polymorphisms were evaluated as possibly associated with end-stage renal disease (ESRD) resulting from type 2 diabetes mellitus (DM) nephropathy.
Methods.
Studies were conducted among hemodialysis (HD) patients with ESRD due to type 2 DM nephropathy, chronic glomerulonephritis, chronic infective tubulointerstitial nephritis, and hypertensive nephropathy as well as in healthy subjects.
A frequency distribution of T-cell-related interleukin (IL) genes (IL18 rs360719, IL12A rs568408, IL12B rs3212227, IL4R rs1805015, IL13 rs20541, IL28B rs8099917, IL28B, and rs12979860) and vitamin D pathway genes (GC genes: rs2298849, rs7041, and rs1155563; VDR genes: rs2228570, rs1544410; and RXRA genes: rs10776909, rs10881578, and rs749759) was compared between groups.
Results.
No significant differences in a frequency distribution of tested polymorphisms were shown between type 2 DM nephropathy patients and controls.
A difference was found in IL18 rs360719 polymorphic distribution between the former group and chronic infective tubulointerstitial nephritic patients (Ptrend=0.033), which also differed in this polymorphism from controls (Ptrend=0.005).
Conclusion.
T-cell cytokine and vitamin D pathway gene polymorphisms are not associated with ESRD due to type 2 DM nephropathy in Polish HD patients.
IL18 rs360719 is probably associated with the pathogenesis of chronic infective tubulointerstitial nephritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grzegorzewska, Alicja E.& Ostromecki, Grzegorz& Zielińska, Paulina& Mostowska, Adrianna& Jagodziński, Paweł P.. 2014. T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1040222
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grzegorzewska, Alicja E.…[et al.]. T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease. Journal of Diabetes Research No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1040222
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grzegorzewska, Alicja E.& Ostromecki, Grzegorz& Zielińska, Paulina& Mostowska, Adrianna& Jagodziński, Paweł P.. T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1040222
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040222
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر