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T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease
المؤلفون المشاركون
Grzegorzewska, Alicja E.
Ostromecki, Grzegorz
Zielińska, Paulina
Mostowska, Adrianna
Jagodziński, Paweł P.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-22
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Background.
T-cell cytokine gene polymorphisms and vitamin D pathway gene polymorphisms were evaluated as possibly associated with end-stage renal disease (ESRD) resulting from type 2 diabetes mellitus (DM) nephropathy.
Methods.
Studies were conducted among hemodialysis (HD) patients with ESRD due to type 2 DM nephropathy, chronic glomerulonephritis, chronic infective tubulointerstitial nephritis, and hypertensive nephropathy as well as in healthy subjects.
A frequency distribution of T-cell-related interleukin (IL) genes (IL18 rs360719, IL12A rs568408, IL12B rs3212227, IL4R rs1805015, IL13 rs20541, IL28B rs8099917, IL28B, and rs12979860) and vitamin D pathway genes (GC genes: rs2298849, rs7041, and rs1155563; VDR genes: rs2228570, rs1544410; and RXRA genes: rs10776909, rs10881578, and rs749759) was compared between groups.
Results.
No significant differences in a frequency distribution of tested polymorphisms were shown between type 2 DM nephropathy patients and controls.
A difference was found in IL18 rs360719 polymorphic distribution between the former group and chronic infective tubulointerstitial nephritic patients (Ptrend=0.033), which also differed in this polymorphism from controls (Ptrend=0.005).
Conclusion.
T-cell cytokine and vitamin D pathway gene polymorphisms are not associated with ESRD due to type 2 DM nephropathy in Polish HD patients.
IL18 rs360719 is probably associated with the pathogenesis of chronic infective tubulointerstitial nephritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grzegorzewska, Alicja E.& Ostromecki, Grzegorz& Zielińska, Paulina& Mostowska, Adrianna& Jagodziński, Paweł P.. 2014. T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1040222
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grzegorzewska, Alicja E.…[et al.]. T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease. Journal of Diabetes Research No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1040222
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grzegorzewska, Alicja E.& Ostromecki, Grzegorz& Zielińska, Paulina& Mostowska, Adrianna& Jagodziński, Paweł P.. T-Cell Cytokine Gene Polymorphisms and Vitamin D Pathway Gene Polymorphisms in End-Stage Renal Disease due to Type 2 Diabetes Mellitus Nephropathy: Comparisons with Health Status and Other Main Causes of End-Stage Renal Disease. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1040222
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040222
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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