Data Mining for Identifying Novel Associations and Temporal Relationships with Charcot Foot
المؤلفون المشاركون
Munson, Michael E.
Holmes, Crystal M.
Hanauer, David A.
Wrobel, James S.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Introduction.
Charcot foot is a rare and devastating complication of diabetes.
While some risk factors are known, debate continues regarding etiology.
Elucidating other associated disorders and their temporal occurrence could lead to a better understanding of its pathogenesis.
We applied a large data mining approach to Charcot foot for elucidating novel associations.
Methods.
We conducted an association analysis using ICD-9 diagnosis codes for every patient in our health system ( n = 1.6 million with 41.2 million time-stamped ICD-9 codes).
For the current analysis, we focused on the 388 patients with Charcot foot (ICD-9 713.5).
Results.
We found 710 associations, 676 (95.2%) of which had a P value for the association less than 1.0 × 10 − 5 and 603 (84.9%) of which had an odds ratio > 5.0.
There were 111 (15.6%) associations with a significant temporal relationship P < 1.0 × 10 − 3 .
The three novel associations with the strongest temporal component were cardiac dysrhythmia, pulmonary eosinophilia, and volume depletion disorder.
Conclusion.
We identified novel associations with Charcot foot in the context of pathogenesis models that include neurotrophic, neurovascular, and microtraumatic factors mediated through inflammatory cytokines.
Future work should focus on confirmatory analyses.
These novel areas of investigation could lead to prevention or earlier diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Munson, Michael E.& Wrobel, James S.& Holmes, Crystal M.& Hanauer, David A.. 2014. Data Mining for Identifying Novel Associations and Temporal Relationships with Charcot Foot. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040261
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Munson, Michael E.…[et al.]. Data Mining for Identifying Novel Associations and Temporal Relationships with Charcot Foot. Journal of Diabetes Research No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1040261
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Munson, Michael E.& Wrobel, James S.& Holmes, Crystal M.& Hanauer, David A.. Data Mining for Identifying Novel Associations and Temporal Relationships with Charcot Foot. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040261
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040261
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر