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Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM
المؤلفون المشاركون
Polat, Sefika Burcak
Ersoy, Reyhan
Cakir, Bekir
Ugurlu, Nagihan
Yulek, Fatma
Simavli, Huseyin
Erel, Ozcan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Diabetic retinopathy (DR) is the leading cause of blindness in the world.
Retinopathy can still progress despite optimal metabolic control.
The aim of the study was to determine whether different degrees of DR (proliferative or nonproliferative) were associated with abnormally modulated hemostatic parameters in patients with T1DM.
Method.
52 T1DM patients and 40 healthy controls were enrolled in the study.
Patients were subdivided into three categories.
Group I was defined as those without retinopathy, group II with NPRP, and group III with PRP.
We compared these subgroups with each other and the control group (Group IV) according to the serum fibrinogen, plasminogen, alpha2-anti-plasmin (α2-anti-plasmin), and PAI.
Results.
We detected that PAI-1, serum fibrinogen, and plasminogen levels were similar between the diabetic and control groups ( P = 0.209 , P = 0.224 , and P = 0.244 , resp.), whereas α2-anti-plasmin was higher in Groups I, II, and III compared to the control group ( P < 0.01 , P < 0.05 , and P < 0.001 , resp.).
There was a positive correlation between serum α2-anti-plasmin and HbA1c levels ( r = 0,268 , P = 0.031 ).
Conclusion.
To our knowledge there is scarce data in the literature about α2-anti-plasmin levels in type 1 diabetes.
A positive correlation between α2-anti-plasmin with HbA1c suggests that fibrinolytic markers may improve with disease regulation and better glycemic control.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Polat, Sefika Burcak& Ugurlu, Nagihan& Yulek, Fatma& Simavli, Huseyin& Ersoy, Reyhan& Cakir, Bekir…[et al.]. 2014. Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040286
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Polat, Sefika Burcak…[et al.]. Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040286
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Polat, Sefika Burcak& Ugurlu, Nagihan& Yulek, Fatma& Simavli, Huseyin& Ersoy, Reyhan& Cakir, Bekir…[et al.]. Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040286
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040286
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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