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Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM
Joint Authors
Polat, Sefika Burcak
Ersoy, Reyhan
Cakir, Bekir
Ugurlu, Nagihan
Yulek, Fatma
Simavli, Huseyin
Erel, Ozcan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Diabetic retinopathy (DR) is the leading cause of blindness in the world.
Retinopathy can still progress despite optimal metabolic control.
The aim of the study was to determine whether different degrees of DR (proliferative or nonproliferative) were associated with abnormally modulated hemostatic parameters in patients with T1DM.
Method.
52 T1DM patients and 40 healthy controls were enrolled in the study.
Patients were subdivided into three categories.
Group I was defined as those without retinopathy, group II with NPRP, and group III with PRP.
We compared these subgroups with each other and the control group (Group IV) according to the serum fibrinogen, plasminogen, alpha2-anti-plasmin (α2-anti-plasmin), and PAI.
Results.
We detected that PAI-1, serum fibrinogen, and plasminogen levels were similar between the diabetic and control groups ( P = 0.209 , P = 0.224 , and P = 0.244 , resp.), whereas α2-anti-plasmin was higher in Groups I, II, and III compared to the control group ( P < 0.01 , P < 0.05 , and P < 0.001 , resp.).
There was a positive correlation between serum α2-anti-plasmin and HbA1c levels ( r = 0,268 , P = 0.031 ).
Conclusion.
To our knowledge there is scarce data in the literature about α2-anti-plasmin levels in type 1 diabetes.
A positive correlation between α2-anti-plasmin with HbA1c suggests that fibrinolytic markers may improve with disease regulation and better glycemic control.
American Psychological Association (APA)
Polat, Sefika Burcak& Ugurlu, Nagihan& Yulek, Fatma& Simavli, Huseyin& Ersoy, Reyhan& Cakir, Bekir…[et al.]. 2014. Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040286
Modern Language Association (MLA)
Polat, Sefika Burcak…[et al.]. Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040286
American Medical Association (AMA)
Polat, Sefika Burcak& Ugurlu, Nagihan& Yulek, Fatma& Simavli, Huseyin& Ersoy, Reyhan& Cakir, Bekir…[et al.]. Evaluation of Serum Fibrinogen, Plasminogen, α2-Anti-Plasmin, and Plasminogen Activator Inhibitor Levels (PAI) and Their Correlation with Presence of Retinopathy in Patients with Type 1 DM. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040286