The GLP-1 Analogue Exenatide Improves Hepatic and Muscle Insulin Sensitivity in Diabetic Rats: Tracer Studies in the Basal State and during Hyperinsulinemic-Euglycemic Clamp

المؤلفون المشاركون

Weng, Pan
Zhang, Huixin
Lu, Yingli
Wu, Hui
Sui, Chunhua
Xu, Hui
Xia, Fangzhen
Zhai, Hualing
Han, Bing
Du, Sichun

المصدر

Journal of Diabetes Research

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-11-13

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Objective.

Glucagon-like peptide-1 (GLP-1) analogues (e.g., exenatide) increase insulin secretion in diabetes but less is known about their effects on glucose production or insulin-stimulated glucose uptake in peripheral tissues.

Methods.

Four groups of Sprague-Dawley rats were studied: nondiabetic (control, C); nondiabetic + exenatide (C + E); diabetic (D); diabetic + exenatide (D + E) with diabetes induced by streptozotocin and high fat diet.

Infusion of 3-3H-glucose and U-13C-glycerol was used to measure basal rates of appearance ( R a ) of glucose and glycerol and gluconeogenesis from glycerol (GNG).

During hyperinsulinemic-euglycemic clamp, glucose uptake into gastrocnemius muscles was measured with 2-deoxy-D-14C-glucose.

Results.

In the diabetic rats, exenatide reduced the basal R a of glucose ( P < 0.01 ) and glycerol ( P < 0.01 ) and GNG ( P < 0.001 ).

During the clamp, R a of glucose was also reduced, whereas the rate of disappearance of glucose increased and there was increased glucose uptake into muscle ( P < 0.01 ) during the clamp.

In the nondiabetic rats, exenatide had no effect.

Conclusion.

In addition to its known effects on insulin secretion, administration of the GLP-1 analogue, exenatide, is associated with increased inhibition of gluconeogenesis and improved glucose uptake into muscle in diabetic rats, implying improved hepatic and peripheral insulin sensitivity.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Hui& Sui, Chunhua& Xu, Hui& Xia, Fangzhen& Zhai, Hualing& Zhang, Huixin…[et al.]. 2014. The GLP-1 Analogue Exenatide Improves Hepatic and Muscle Insulin Sensitivity in Diabetic Rats: Tracer Studies in the Basal State and during Hyperinsulinemic-Euglycemic Clamp. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040306

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Hui…[et al.]. The GLP-1 Analogue Exenatide Improves Hepatic and Muscle Insulin Sensitivity in Diabetic Rats: Tracer Studies in the Basal State and during Hyperinsulinemic-Euglycemic Clamp. Journal of Diabetes Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040306

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Hui& Sui, Chunhua& Xu, Hui& Xia, Fangzhen& Zhai, Hualing& Zhang, Huixin…[et al.]. The GLP-1 Analogue Exenatide Improves Hepatic and Muscle Insulin Sensitivity in Diabetic Rats: Tracer Studies in the Basal State and during Hyperinsulinemic-Euglycemic Clamp. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040306

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1040306