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Cardiomyopathy in Offspring of Pregestational Diabetic Mouse Pregnancy
المؤلفون المشاركون
Baugh, John
Watson, Chris J.
Dowling, Daniel
Corrigan, Niamh
Horgan, Stephen
Downey, Paul
McAuliffe, Fionnuala M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate cardiomyopathy in offspring in a mouse model of pregestational type 1 diabetic pregnancy.
Methods.
Pregestational diabetes was induced with STZ administration in female C57BL6/J mice that were subsequently mated with healthy C57BL6/J males.
Offspring were sacrificed at embryonic day 18.5 and 6-week adolescent and 12-week adult stages.
The size and number of cardiomyocyte nuclei and also the extent of collagen deposition within the hearts of diabetic and control offspring were assessed following cardiac tissue staining with either haematoxylin and eosin or Picrosirius red and subsequently quantified using automated digital image analysis.
Results.
Offspring from diabetic mice at embryonic day 18.5 had a significantly higher number of cardiomyocyte nuclei present compared to controls.
These nuclei were also significantly smaller than controls.
Collagen deposition was shown to be significantly increased in the hearts of diabetic offspring at the same age.
No significant differences were found between the groups at 6 and 12 weeks.
Conclusions.
Our results from offspring of type 1 diabetic mice show increased myocardial collagen deposition in late gestation and have increased myocardial nuclear counts (hyperplasia) as opposed to increased myocardial nuclear size (hypertrophy) in late gestation.
These changes normalize postpartum after removal from the maternal intrauterine environment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dowling, Daniel& Corrigan, Niamh& Horgan, Stephen& Watson, Chris J.& Baugh, John& Downey, Paul…[et al.]. 2014. Cardiomyopathy in Offspring of Pregestational Diabetic Mouse Pregnancy. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040317
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dowling, Daniel…[et al.]. Cardiomyopathy in Offspring of Pregestational Diabetic Mouse Pregnancy. Journal of Diabetes Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040317
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dowling, Daniel& Corrigan, Niamh& Horgan, Stephen& Watson, Chris J.& Baugh, John& Downey, Paul…[et al.]. Cardiomyopathy in Offspring of Pregestational Diabetic Mouse Pregnancy. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040317
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040317
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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