The Effect of Chromium Picolinate Supplementation on the Pancreas and Macroangiopathy in Type II Diabetes Mellitus Rats
المؤلفون المشاركون
Huang, Shan
Peng, Wenfang
Jiang, Xiaohong
Shao, Kan
Xia, Lili
Tang, Yubin
Qiu, Jiayin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats.
Methods.
The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ).
The rats were randomly divided into 5 groups (ten rats in each group).
After supplementing CrPic for 15 weeks, the histopathological examination was performed by hematoxylin-eosin (HE) staining.
Serum insulin and NO level were determined by radioimmunoassay and colorimetry, respectively.
Serum glycosylated hemoglobin (HbA1C), adiponectin (APN), advanced glycation end products (AGES), and apelin were measured by ELISA.
Real-time reverse transcription polymerase chain reaction (RT-PCR) was applied for detecting the mRNA expression of APN and apelin.
Results.
After CrPic treatment, compared with the T2DM control group (group 2), pancreas sections stained with HE showed the completed pancreatic cells structure and no inflammatory infiltration in groups 4 and 5.
In addition, the levels of serum NO and insulin were significantly increased and the serum levels of HbA1C, AGES, APN, and apelin were significantly decreased in groups 4 and 5 compared with group 2.
The mRNA expression of APN and apelin in groups 4 and 5 was also recovered to the normal level.
Conclusion.
CrPic can recover the function of Β-cells and alleviate macroangiopathy in STZ-induced T2DM rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Shan& Peng, Wenfang& Jiang, Xiaohong& Shao, Kan& Xia, Lili& Tang, Yubin…[et al.]. 2014. The Effect of Chromium Picolinate Supplementation on the Pancreas and Macroangiopathy in Type II Diabetes Mellitus Rats. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040345
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Shan…[et al.]. The Effect of Chromium Picolinate Supplementation on the Pancreas and Macroangiopathy in Type II Diabetes Mellitus Rats. Journal of Diabetes Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040345
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Shan& Peng, Wenfang& Jiang, Xiaohong& Shao, Kan& Xia, Lili& Tang, Yubin…[et al.]. The Effect of Chromium Picolinate Supplementation on the Pancreas and Macroangiopathy in Type II Diabetes Mellitus Rats. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040345
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040345
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر