Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic dbdb Mice by Inhibition of Hepatic Gluconeogenesis
المؤلفون المشاركون
Kim, Sujong
Lee, Young-Sun
Lee, Eun-Kyu
Oh, Hyun-Hee
Choi, Cheol Soo
Jun, Hee-Sook
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Sodium meta-arsenite (SA) is implicated in the regulation of hepatic gluconeogenesis-related genes in vitro; however, the effects in vivo have not been studied.
We investigated whether SA has antidiabetic effects in a type 2 diabetic mouse model.
Diabetic db/db mice were orally intubated with SA (10 mg kg−1 body weight/day) for 8 weeks.
We examined hemoglobin A1c (HbA1c), blood glucose levels, food intake, and body weight.
We performed glucose, insulin, and pyruvate tolerance tests and analyzed glucose production and the expression of gluconeogenesis-related genes in hepatocytes.
We analyzed energy metabolism using a comprehensive animal metabolic monitoring system.
SA-treated diabetic db/db mice had reduced concentrations of HbA1c and blood glucose levels.
Exogenous glucose was quickly cleared in glucose tolerance tests.
The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice.
In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4α) mRNA.
Small heterodimer partner (SHP) mRNA expression was increased in hepatocytes dependent upon the SA concentration.
The expression of Sirt1 mRNA and protein was reduced, and acetylated forkhead box protein O1 (FoxO1) was induced by SA treatment in hepatocytes.
In addition, SA-treated diabetic db/db mice showed reduced energy expenditure.
Oral intubation of SA ameliorates hyperglycemia in db/db mice by reducing hepatic gluconeogenesis through the decrease of Sirt1 expression and increase in acetylated FoxO1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Young-Sun& Lee, Eun-Kyu& Oh, Hyun-Hee& Choi, Cheol Soo& Kim, Sujong& Jun, Hee-Sook. 2014. Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic dbdb Mice by Inhibition of Hepatic Gluconeogenesis. Journal of Diabetes Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040403
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Young-Sun…[et al.]. Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic dbdb Mice by Inhibition of Hepatic Gluconeogenesis. Journal of Diabetes Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040403
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Young-Sun& Lee, Eun-Kyu& Oh, Hyun-Hee& Choi, Cheol Soo& Kim, Sujong& Jun, Hee-Sook. Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic dbdb Mice by Inhibition of Hepatic Gluconeogenesis. Journal of Diabetes Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040403
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040403
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر