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GK-1 Improves the Immune Response Induced by Bone Marrow Dendritic Cells Loaded with MAGE-AX in Mice with Melanoma
المؤلفون المشاركون
Piñón-Zárate, Gabriela
Herrera-Enríquez, Miguel Ángel
Hernández-Téllez, Beatriz
Jarquín-Yáñez, Katia
Castell-Rodríguez, Andrés Eliú
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The aim of dendritic cell (DC) vaccination in cancer is to induce tumor-specific effector T cells that may reduce and control tumor mass.
Immunostimulants that could drive a desired immune response are necessary to be found in order to generate a long lasting tumor immune response.
GK-1 peptide, derived from Taenia crassiceps, induces not only increase in TNFα, IFNγ, and MCP-1 production in cocultures of DCs and T lymphocytes but also immunological protection against influenza virus.
Moreover, the aim of this investigation is the use of GK-1 as a bone marrow DCs (BMDCs) immunostimulant targeted with MAGE antigen; thus, BMDC may be used as immunotherapy against murine melanoma.
GK-1 induced in BMDCs a meaningful increment of CD86 and IL-12.
In addition, the use of BMDCs TNFα/GK-1/MAGE-AX induced the highest survival and the smallest tumors in mice.
Besides, the treatment helped to increase CD8 lymphocytes levels and to produce IFNγ in lymph nodes.
Moreover, the histopathological analysis showed that BMDCs treated with GK-1/TNFα and loaded with MAGE-AX induced the apparition of more apoptotic and necrotic areas in tumors than in mice without treatment.
These results highlight the properties of GK-1 as an immunostimulant of DCs and suggest as a potential candidate the use of this immunotherapy against cancer disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Piñón-Zárate, Gabriela& Herrera-Enríquez, Miguel Ángel& Hernández-Téllez, Beatriz& Jarquín-Yáñez, Katia& Castell-Rodríguez, Andrés Eliú. 2014. GK-1 Improves the Immune Response Induced by Bone Marrow Dendritic Cells Loaded with MAGE-AX in Mice with Melanoma. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Piñón-Zárate, Gabriela…[et al.]. GK-1 Improves the Immune Response Induced by Bone Marrow Dendritic Cells Loaded with MAGE-AX in Mice with Melanoma. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Piñón-Zárate, Gabriela& Herrera-Enríquez, Miguel Ángel& Hernández-Téllez, Beatriz& Jarquín-Yáñez, Katia& Castell-Rodríguez, Andrés Eliú. GK-1 Improves the Immune Response Induced by Bone Marrow Dendritic Cells Loaded with MAGE-AX in Mice with Melanoma. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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