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Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus
المؤلفون المشاركون
Ramos, Celso Darío
Sinicato, Nailú Angélica
Postal, Mariana
Peres, Fernando Augusto
Peliçari, Karina de Oliveira
Marini, Roberto
dos Santos, Allan de Oliveira
Appenzeller, Simone
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
In systemic lupus erythematosus (SLE), atherosclerosis is attributed to traditional and lupus related risk factors, including metabolic syndrome (MetS), obesity, and inflammation.
Objective.
To evaluate the association between obesity, measures of body fat content, serum tumor necrosis factor alpha (TNF- α ), and interleukin (IL)-6 and -10 levels in childhood-onset SLE (cSLE).
Methods.
We screened consecutive cSLE patients followed up in the Pediatric Rheumatology Outpatient Clinic of the State University of Campinas.
cSLE patients were assessed for disease and damage.
Obesity was definite as body mass index (BMI) ≥30 kg/m2.
Serum TNF- α , IL-6, and IL-10 levels were measured by ELISA.
Dual-energy X-ray absorptiometry was used to determine total fat mass, lean mass, and percent of body fat.
Results.
We included 52 cSLE patients and 52 controls.
cSLE patients had higher serum TNF- α ( P = 0.004 ) , IL-6 ( P = 0.002 ) , and IL-10 ( P < 0.001 ) levels compared to controls.
We observed higher serum TNF- α ( P = 0.036 ) levels in cSLE patients with obesity.
An association between serum TNF- α levels and body fat percent ( P = 0.046 ) and total fat mass on trunk region ( P = 0.035 ) was observed.
Conclusion.
Serum TNF- α levels were associated with obesity and body fat content in cSLE.
Our finding suggests that obesity may contribute to the increase of serum TNF- α levels in cSLE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sinicato, Nailú Angélica& Postal, Mariana& Peres, Fernando Augusto& Peliçari, Karina de Oliveira& Marini, Roberto& dos Santos, Allan de Oliveira…[et al.]. 2014. Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040780
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sinicato, Nailú Angélica…[et al.]. Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus. Journal of Immunology Research No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1040780
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sinicato, Nailú Angélica& Postal, Mariana& Peres, Fernando Augusto& Peliçari, Karina de Oliveira& Marini, Roberto& dos Santos, Allan de Oliveira…[et al.]. Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1040780
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040780
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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