Proatherogenic Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes in Arterial and Venous Disease

المؤلفون المشاركون

Berger, Jeffrey S.
Rockman, Caron B.
Guyer, Kirk E.
Lopez, Luis R.

المصدر

Journal of Immunology Research

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-10-27

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأحياء

الملخص EN

OxLDL/β2GPI complexes have been implicated in the initiation and progression of atherosclerosis and associated with disease severity and adverse outcomes.

We investigate the significance of anti-oxLDL/β2GPI antibodies and oxLDL/β2GPI complexes in patients with arterial and idiopathic venous disease.

A cohort of 61 arterial disease patients, 32 idiopathic venous disease patients, and 53 healthy controls was studied.

Because statins influence oxLDL/β2GPI, these complexes were analyzed on subjects not taking statins.

Arterial and venous groups expressed higher levels of IgG anti-oxLDL/β2GPI antibodies than controls without any other significant clinical association.

OxLDL/β2GPI complexes were significantly elevated in arterial (0.69 U/mL, P=0.004) and venous disease (0.54 U/mL, P=0.025) than controls (0.39 U/mL).

Among arterial diseases, oxLDL/β2GPI was 0.85 U/mL for carotid artery disease, 0.72 U/mL for peripheral artery disease, and 0.52 U/mL for abdominal aortic aneurysm.

There was a significant association with male gender, age, hypertension, and history of thrombosis.

Subjects with oxLDL/β2GPI above the median (0.25 U/mL) were more likely to have arterial (OR 4.5, P=0.004) or venous disease (OR 4.1, P=0.008).

Multivariate regression indicated that males (P=0.021), high cholesterol (P=0.011), and carotid disease (P=0.023) were significant predictors of oxLDL/β2GPI.

The coexistence of oxLDL/β2GPI in arterial and venous disease may suggest a common oxidative mechanism that independently predicts carotid artery disease.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Berger, Jeffrey S.& Rockman, Caron B.& Guyer, Kirk E.& Lopez, Luis R.. 2014. Proatherogenic Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes in Arterial and Venous Disease. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040795

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Berger, Jeffrey S.…[et al.]. Proatherogenic Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes in Arterial and Venous Disease. Journal of Immunology Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1040795

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Berger, Jeffrey S.& Rockman, Caron B.& Guyer, Kirk E.& Lopez, Luis R.. Proatherogenic Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes in Arterial and Venous Disease. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040795

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1040795