Proatherogenic Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes in Arterial and Venous Disease
Joint Authors
Berger, Jeffrey S.
Rockman, Caron B.
Guyer, Kirk E.
Lopez, Luis R.
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
OxLDL/β2GPI complexes have been implicated in the initiation and progression of atherosclerosis and associated with disease severity and adverse outcomes.
We investigate the significance of anti-oxLDL/β2GPI antibodies and oxLDL/β2GPI complexes in patients with arterial and idiopathic venous disease.
A cohort of 61 arterial disease patients, 32 idiopathic venous disease patients, and 53 healthy controls was studied.
Because statins influence oxLDL/β2GPI, these complexes were analyzed on subjects not taking statins.
Arterial and venous groups expressed higher levels of IgG anti-oxLDL/β2GPI antibodies than controls without any other significant clinical association.
OxLDL/β2GPI complexes were significantly elevated in arterial (0.69 U/mL, P=0.004) and venous disease (0.54 U/mL, P=0.025) than controls (0.39 U/mL).
Among arterial diseases, oxLDL/β2GPI was 0.85 U/mL for carotid artery disease, 0.72 U/mL for peripheral artery disease, and 0.52 U/mL for abdominal aortic aneurysm.
There was a significant association with male gender, age, hypertension, and history of thrombosis.
Subjects with oxLDL/β2GPI above the median (0.25 U/mL) were more likely to have arterial (OR 4.5, P=0.004) or venous disease (OR 4.1, P=0.008).
Multivariate regression indicated that males (P=0.021), high cholesterol (P=0.011), and carotid disease (P=0.023) were significant predictors of oxLDL/β2GPI.
The coexistence of oxLDL/β2GPI in arterial and venous disease may suggest a common oxidative mechanism that independently predicts carotid artery disease.
American Psychological Association (APA)
Berger, Jeffrey S.& Rockman, Caron B.& Guyer, Kirk E.& Lopez, Luis R.. 2014. Proatherogenic Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes in Arterial and Venous Disease. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040795
Modern Language Association (MLA)
Berger, Jeffrey S.…[et al.]. Proatherogenic Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes in Arterial and Venous Disease. Journal of Immunology Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1040795
American Medical Association (AMA)
Berger, Jeffrey S.& Rockman, Caron B.& Guyer, Kirk E.& Lopez, Luis R.. Proatherogenic Oxidized Low-Density Lipoproteinβ2-Glycoprotein I Complexes in Arterial and Venous Disease. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040795