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Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity
المؤلفون المشاركون
Pedersen, S. B.
Fjeldborg, Karen
Møller, Holger J.
Christiansen, Tore
Bennetzen, Marianne
Richelsen, B.
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Adipose tissue (AT) macrophages are increased in obesity and associated with low grade inflammation.
We aimed to characterize the phenotype of AT macrophages in humans in relation to obesity and insulin resistance.
Design.
Gene-expression levels of general macrophage markers (CD68 and CD14), proinflammatory markers/M1 (TNF-α, MCP-1, and IL-6), and anti-inflammatory markers/M2 (CD163, CD206, and IL-10) were determined by RT-PCR in subcutaneous AT samples from lean and obese subjects.
Insulin resistance was determined by HOMA-IR.
Results.
All the macrophage markers were elevated in the AT from obese compared to lean subjects ( P < 0.001 ).
To determine the phenotype of the macrophages the level of CD14 was used to adjust the total number of macrophages.
The relative expression of CD163 and IL-10 was elevated, and TNF-α and IL-6 were reduced in AT from obese subjects (all P < 0.05 ).
In a multivariate regression analysis CD163 was the only macrophage marker significantly associated with HOMA-IR (β: 0.57; P < 0.05 ).
Conclusion.
Obesity is associated with elevated numbers of macrophages in the AT.
Unexpectedly, the macrophages change phenotype by obesity, with a preponderance of M2 and a decrement of M1 markers in AT from obese subjects.
Moreover, CD163 was the only macrophage marker associated with HOMA-IR after multiple adjustments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fjeldborg, Karen& Pedersen, S. B.& Møller, Holger J.& Christiansen, Tore& Bennetzen, Marianne& Richelsen, B.. 2014. Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fjeldborg, Karen…[et al.]. Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1040834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fjeldborg, Karen& Pedersen, S. B.& Møller, Holger J.& Christiansen, Tore& Bennetzen, Marianne& Richelsen, B.. Human Adipose Tissue Macrophages Are Enhanced but Changed to an Anti-Inflammatory Profile in Obesity. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1040834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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