![](/images/graphics-bg.png)
TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development
المؤلفون المشاركون
Ortega, Enrique
Tirado-Rodriguez, Belen
Segura-Medina, Patricia
Huerta-Yepez, Sara
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-11
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The transforming growth factor-β (TGF-β) superfamily is a family of structurally related proteins that includes TGF-β, activins/inhibins, and bone morphogenic proteins (BMPs).
Members of the TGF-β superfamily regulate cellular functions such as proliferation, apoptosis, differentiation, and migration and thus play key roles in organismal development.
TGF-β is involved in several human diseases, including autoimmune disorders and vascular diseases.
Activation of the TGF-β receptor induces phosphorylation of serine/threonine residues and triggers phosphorylation of intracellular effectors (Smads).
Once activated, Smad proteins translocate to the nucleus and induce transcription of their target genes, regulating various processes and cellular functions.
Recently, there has been an attempt to correlate the effect of TGF-β with various pathological entities such as allergic diseases and cancer, yielding a new area of research known as “allergooncology," which investigates the mechanisms by which allergic diseases may influence the progression of certain cancers.
This knowledge could generate new therapeutic strategies aimed at correcting the pathologies in which TGF-β is involved.
Here, we review recent studies that suggest an important role for TGF-β in both allergic disease and cancer progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tirado-Rodriguez, Belen& Ortega, Enrique& Segura-Medina, Patricia& Huerta-Yepez, Sara. 2014. TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tirado-Rodriguez, Belen…[et al.]. TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development. Journal of Immunology Research No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1040838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tirado-Rodriguez, Belen& Ortega, Enrique& Segura-Medina, Patricia& Huerta-Yepez, Sara. TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)