TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development
Joint Authors
Ortega, Enrique
Tirado-Rodriguez, Belen
Segura-Medina, Patricia
Huerta-Yepez, Sara
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The transforming growth factor-β (TGF-β) superfamily is a family of structurally related proteins that includes TGF-β, activins/inhibins, and bone morphogenic proteins (BMPs).
Members of the TGF-β superfamily regulate cellular functions such as proliferation, apoptosis, differentiation, and migration and thus play key roles in organismal development.
TGF-β is involved in several human diseases, including autoimmune disorders and vascular diseases.
Activation of the TGF-β receptor induces phosphorylation of serine/threonine residues and triggers phosphorylation of intracellular effectors (Smads).
Once activated, Smad proteins translocate to the nucleus and induce transcription of their target genes, regulating various processes and cellular functions.
Recently, there has been an attempt to correlate the effect of TGF-β with various pathological entities such as allergic diseases and cancer, yielding a new area of research known as “allergooncology," which investigates the mechanisms by which allergic diseases may influence the progression of certain cancers.
This knowledge could generate new therapeutic strategies aimed at correcting the pathologies in which TGF-β is involved.
Here, we review recent studies that suggest an important role for TGF-β in both allergic disease and cancer progression.
American Psychological Association (APA)
Tirado-Rodriguez, Belen& Ortega, Enrique& Segura-Medina, Patricia& Huerta-Yepez, Sara. 2014. TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040838
Modern Language Association (MLA)
Tirado-Rodriguez, Belen…[et al.]. TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development. Journal of Immunology Research No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1040838
American Medical Association (AMA)
Tirado-Rodriguez, Belen& Ortega, Enrique& Segura-Medina, Patricia& Huerta-Yepez, Sara. TGF-β: An Important Mediator of Allergic Disease and a Molecule with Dual Activity in Cancer Development. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1040838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040838