Anti-CD3 Antibody Treatment Induces Hypoglycemia and Super Tolerance to Glucose Challenge in Mice through Enhancing Glucose Consumption by Activated Lymphocytes
المؤلفون المشاركون
Xia, Chang-Qing
Chernatynskaya, Anna V.
Looney, Benjamin
Wan, Suigui
Clare-Salzler, Michael J.
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Anti-CD3 antibody has been employed for various immune-mediated disorders.
However, whether anti-CD3 administration leads to rapid metabolic alternation has not been well investigated.
In the current study, we studied how anti-CD3 treatment affected blood glucose levels in mice.
We found that anti-CD3 treatment induced immediate reduction of blood glucose after administration.
Furthermore, a single dose of anti-CD3 treatment corrected hyperglycemia in all nonobese diabetic mice with recently diagnosed diabetes.
This glucose-lowering effect was not attributable to major T cell produced cytokines.
Of interest, when tested in a normal strain of mice (C57BL/6), the serum levels of C-peptide in anti-CD3 treated animals were significantly lower than control mice.
Paradoxically, anti-CD3 treated animals were highly tolerant to exogenous glucose challenge.
Additionally, we found that anti-CD3 treatment significantly induced activation of T and B cells in vitro and in vivo.
Further studies demonstrated that anti-CD3 treatment lowered the glucose levels in T cell culture media and increased the intracellular transportation of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2 deoxyglucose (2-NBDG) particularly in activated T and B cells.
In addition, injection of anti-CD3 antibodies induced enhanced levels of Glut1 expression in spleen cells.
This study suggests that anti-CD3 therapy-induced hypoglycemia likely results from increased glucose transportation and consumption by the activated lymphocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xia, Chang-Qing& Chernatynskaya, Anna V.& Looney, Benjamin& Wan, Suigui& Clare-Salzler, Michael J.. 2014. Anti-CD3 Antibody Treatment Induces Hypoglycemia and Super Tolerance to Glucose Challenge in Mice through Enhancing Glucose Consumption by Activated Lymphocytes. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040843
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xia, Chang-Qing…[et al.]. Anti-CD3 Antibody Treatment Induces Hypoglycemia and Super Tolerance to Glucose Challenge in Mice through Enhancing Glucose Consumption by Activated Lymphocytes. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040843
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xia, Chang-Qing& Chernatynskaya, Anna V.& Looney, Benjamin& Wan, Suigui& Clare-Salzler, Michael J.. Anti-CD3 Antibody Treatment Induces Hypoglycemia and Super Tolerance to Glucose Challenge in Mice through Enhancing Glucose Consumption by Activated Lymphocytes. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040843
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040843
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر