Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer
المؤلفون المشاركون
Kim, Yong-Beom
Kim, Se Ik
Kim, Hee Seung
Kim, Kidong
No, Jae Hong
Chung, Hyun Hoon
Kim, Tae Hun
Suh, Dong Hoon
Song, Yong-Sang
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study aimed to investigate the impact of underweight status on the prognosis of advanced-stage ovarian cancer.
A total of 360 patients with stage III-IV epithelial ovarian cancer were enrolled and divided into three groups by body mass indexes (BMIs): underweight (BMI < 18.5 kg/m2); normal weight to overweight (18.5 kg/m2 BMI < 27.5 kg/m2); obesity (BMI ≥ 27.5 kg/m2).
Progression-free survival (PFS), overall survival (OS), CA-125, and neutrophil to lymphocyte ratio (NLR) as a marker reflecting host inflammation and immunity were compared among the three groups according to the three treatment times: at diagnosis; after surgery; and after treatment.
Only underweight status after treatment was associated with poor OS in comparison with normal weight to overweight or obesity (mean value, 44.9 versus 78.8 or 67.4 months; P = 0.05 ); it was also an unfavorable factor for OS (adjusted HR, 2.29; 95% CI, 1.08–4.85).
Furthermore, NLR was higher in patients with underweight than in those with obesity after treatment (median value, 2.15 versus 1.47; P = 0.03 ), in spite of no difference in CA-125 among the three groups at the three treatment times.
In conclusion, underweight status after treatment may be a poor prognostic factor in patients with advanced-stage ovarian cancer, which accompanies increased host inflammation and decreased immunity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Se Ik& Kim, Hee Seung& Kim, Tae Hun& Suh, Dong Hoon& Kim, Kidong& No, Jae Hong…[et al.]. 2014. Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040847
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Se Ik…[et al.]. Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040847
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Se Ik& Kim, Hee Seung& Kim, Tae Hun& Suh, Dong Hoon& Kim, Kidong& No, Jae Hong…[et al.]. Impact of Underweight after Treatment on Prognosis of Advanced-Stage Ovarian Cancer. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040847
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040847
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر