The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus
المؤلفون المشاركون
Sun, Xiaolin
Hu, Fanlei
Zhu, Huaqun
Zhu, Lei
Shi, Lianjie
Su, Yin
Long, Li
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE).
Method.
108 SLE patients and 42 healthy controls were recruited in this study.
The expression of mMer on the surfaces of CD14+ monocytes/macrophages was evaluated by flow cytometry (FCM).
The sMer levels were measured by ELISA.
Real-time quantitative PCR was applied to evaluate the mRNA levels of MerTK and ADAM17.
Results.
Both mMer expression on CD14+ monocytes/macrophages and sMer levels in plasma significantly increased in SLE patients compared to healthy subjects.
The frequency of anti-inflammatory MerTK expressing CD14+CD16+ monocytes decreased in SLE.
mMer expression was positively correlated with CD163 expression on CD14+ cells.
Both the mMer expression on CD14+ monocytes/macrophages and sMer levels in plasma were positively correlated with SLEDAI.
Furthermore, more elevated mMer and sMer levels were found in patients with higher SLEDAI, presence of anti-SSA, anti-Sm autoantibodies, and lupus nephritis.
Conclusion.
Both mMer and sMer levels significantly increased in SLE and positively correlated with disease activity and severity.
The upregulation of MerTK expression may serve as a biomarker of the disease activity and severity of SLE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Huaqun& Sun, Xiaolin& Zhu, Lei& Hu, Fanlei& Shi, Lianjie& Long, Li…[et al.]. 2014. The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Huaqun…[et al.]. The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1040868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Huaqun& Sun, Xiaolin& Zhu, Lei& Hu, Fanlei& Shi, Lianjie& Long, Li…[et al.]. The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1040868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر