AlphaBeta T-Cell Depleted Grafts as an Immunological Booster to Treat Graft Failure after Hematopoietic Stem Cell Transplantation with HLA-Matched Related and Unrelated Donors
المؤلفون المشاركون
Rådestad, E.
Wikell, H.
Engström, M.
Watz, E.
Sundberg, B.
Thunberg, S.
Uzunel, M.
Mattsson, J.
Uhlin, M.
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-13
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Allogeneic hematopoietic stem cell transplantation is associated with several complications and risk factors, for example, graft versus host disease (GVHD), viral infections, relapse, and graft rejection.
While high levels of CD3+ cells in grafts can contribute to GVHD, they also promote the graft versus leukemia (GVL) effect.
Infusions of extra lymphocytes from the original stem cell donor can be used as a treatment after transplantation for relapse or poor immune reconstitution but also they increase the risk for GVHD.
In peripheral blood, 95% of T-cells express the αβ T-cell receptor and the remaining T-cells express the γδ T-cell receptor.
As αβ T-cells are the primary mediators of GVHD, depleting them from the graft should reduce this risk.
In this pilot study, five patients transplanted with HLA-matched related and unrelated donors were treated with αβ T-cell depleted stem cell boosts.
The majority of γδ T-cells in the grafts expressed Vδ2 and/or Vγ9.
Most patients receiving αβ-depleted stem cell boosts increased their levels of white blood cells, platelets, and/or granulocytes 30 days after infusion.
No signs of GVHD or other side effects were detected.
A larger pool of patients with longer follow-up time is needed to confirm the data in this study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rådestad, E.& Wikell, H.& Engström, M.& Watz, E.& Sundberg, B.& Thunberg, S.…[et al.]. 2014. AlphaBeta T-Cell Depleted Grafts as an Immunological Booster to Treat Graft Failure after Hematopoietic Stem Cell Transplantation with HLA-Matched Related and Unrelated Donors. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040913
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rådestad, E.…[et al.]. AlphaBeta T-Cell Depleted Grafts as an Immunological Booster to Treat Graft Failure after Hematopoietic Stem Cell Transplantation with HLA-Matched Related and Unrelated Donors. Journal of Immunology Research No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1040913
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rådestad, E.& Wikell, H.& Engström, M.& Watz, E.& Sundberg, B.& Thunberg, S.…[et al.]. AlphaBeta T-Cell Depleted Grafts as an Immunological Booster to Treat Graft Failure after Hematopoietic Stem Cell Transplantation with HLA-Matched Related and Unrelated Donors. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1040913
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040913
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر