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The Many Faces of Human Leukocyte Antigen-G: Relevance to the Fate of Pregnancy
المؤلفون المشاركون
Dahl, Mette
Djurisic, Snezana
Hviid, Thomas Vauvert F.
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Pregnancy is an immunological paradox, where fetal antigens encoded by polymorphic genes inherited from the father do not provoke a maternal immune response.
The fetus is not rejected as it would be theorized according to principles of tissue transplantation.
A major contribution to fetal tolerance is the human leukocyte antigen (HLA)-G, a nonclassical HLA protein displaying limited polymorphism, restricted tissue distribution, and a unique alternative splice pattern.
HLA-G is primarily expressed in placenta and plays multifaceted roles during pregnancy, both as a soluble and a membrane-bound molecule.
Its immunomodulatory functions involve interactions with different immune cells and possibly regulation of cell migration during placental development.
Recent findings include HLA-G contributions from the father and the fetus itself.
Much effort has been put into clarifying the role of HLA-G during pregnancy and pregnancy complications, such as preeclampsia, recurrent spontaneous abortions, and subfertility or infertility.
This review aims to clarify the multifunctional role of HLA-G in pregnancy-related disorders by focusing on genetic variation, differences in mRNA stability between HLA-G alleles, differences in HLA-G isoform expression, and possible differences in functional activity.
Furthermore, we highlight important observations regarding HLA-G genetics and expression in preeclampsia that future research should address.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dahl, Mette& Djurisic, Snezana& Hviid, Thomas Vauvert F.. 2014. The Many Faces of Human Leukocyte Antigen-G: Relevance to the Fate of Pregnancy. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040917
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dahl, Mette…[et al.]. The Many Faces of Human Leukocyte Antigen-G: Relevance to the Fate of Pregnancy. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040917
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dahl, Mette& Djurisic, Snezana& Hviid, Thomas Vauvert F.. The Many Faces of Human Leukocyte Antigen-G: Relevance to the Fate of Pregnancy. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040917
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040917
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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