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Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function
المؤلفون المشاركون
Anderson, Ronald
Theron, A. J.
Tintinger, G. R.
Gravett, C. M.
Feldman, Charles
Steel, Helen C.
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-25
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages.
Notwithstanding potent bronchoconstrictor activity, cysLTs are also proinflammatory consequent to their autocrine and paracrine interactions with G-protein-coupled receptors expressed not only on the aforementioned cell types, but also on Th2 lymphocytes, as well as structural cells, and to a lesser extent neutrophils and CD8+ cells.
Recognition of the involvement of cysLTs in the immunopathogenesis of various types of acute and chronic inflammatory disorders, especially bronchial asthma, prompted the development of selective cysLT receptor-1 (cysLTR1) antagonists, specifically montelukast, pranlukast, and zafirlukast.
More recently these agents have also been reported to possess secondary anti-inflammatory activities, distinct from cysLTR1 antagonism, which appear to be particularly effective in targeting neutrophils and monocytes/macrophages.
Underlying mechanisms include interference with cyclic nucleotide phosphodiesterases, 5′-lipoxygenase, and the proinflammatory transcription factor, nuclear factor kappa B.
These and other secondary anti-inflammatory mechanisms of the commonly used cysLTR1 antagonists are the major focus of the current review, which also includes a comparison of the anti-inflammatory effects of montelukast, pranlukast, and zafirlukast on human neutrophils in vitro, as well as an overview of both the current clinical applications of these agents and potential future applications based on preclinical and early clinical studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Theron, A. J.& Steel, Helen C.& Tintinger, G. R.& Gravett, C. M.& Anderson, Ronald& Feldman, Charles. 2014. Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1040920
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Theron, A. J.…[et al.]. Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function. Journal of Immunology Research No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1040920
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Theron, A. J.& Steel, Helen C.& Tintinger, G. R.& Gravett, C. M.& Anderson, Ronald& Feldman, Charles. Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1040920
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040920
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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