Control of Intracellular Francisella tularensis by Different Cell Types and the Role of Nitric Oxide
المؤلفون المشاركون
Rowland, Caroline A.
Newstead, Sarah L.
Gates, Amanda J.
Hartley, M. Gillian
Lukaszewski, Roman A.
Williamson, Diane
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Reactive nitrogen is critical for the clearance of Francisella tularensis infections.
Here we assess the role of nitric oxide in control of intracellular infections in two murine macrophage cell lines of different provenance: the alveolar macrophage cell line, MH-S, and the widely used peritoneal macrophage cell line, J774A.1.
Cells were infected with the highly virulent Schu S4 strain or with the avirulent live vaccine strain (LVS) with and without stimuli.
Compared to MH-S cells, J774A.1 cells were unresponsive to stimulation and were able to control the intracellular replication of LVS bacteria, but not of Schu S4.
In MH-S cells, Schu S4 demonstrated control over cellular NO production.
Despite this, MH-S cells stimulated with LPS or LPS and IFN- γ were able to control intracellular Schu S4 numbers.
However, only stimulation with LPS induced significant cellular NO production.
Combined stimulation with LPS and IFN- γ produced a significant reduction in intracellular bacteria that occurred whether high levels of NO were produced or not, indicating that NO secretion is not the only defensive cellular mechanism operating in virulent Francisella infections.
Understanding how F.
tularensis interacts with host macrophages will help in the rational design of new and effective therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Newstead, Sarah L.& Gates, Amanda J.& Hartley, M. Gillian& Rowland, Caroline A.& Williamson, Diane& Lukaszewski, Roman A.. 2014. Control of Intracellular Francisella tularensis by Different Cell Types and the Role of Nitric Oxide. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040956
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Newstead, Sarah L.…[et al.]. Control of Intracellular Francisella tularensis by Different Cell Types and the Role of Nitric Oxide. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040956
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Newstead, Sarah L.& Gates, Amanda J.& Hartley, M. Gillian& Rowland, Caroline A.& Williamson, Diane& Lukaszewski, Roman A.. Control of Intracellular Francisella tularensis by Different Cell Types and the Role of Nitric Oxide. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040956
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040956
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر