Association between the −794 (CATT)‎5–8 MIF Gene Polymorphism and Susceptibility to Acute Coronary Syndrome in a Western Mexican Population

الملخص EN

The macrophage migration inhibitory factor (MIF) is related to the progression of atherosclerosis, which, in turn, is a key factor in the development of acute coronary syndrome (ACS).

MIF has a CATT short tandem repeat (STR) at position −794 that might be involved in its expression rate.

The aim of this study was to investigate the association between the −794 CATT5–8 MIF gene polymorphism and susceptibility to ACS in a western Mexican population.

This research included 200 ACS patients classified according to the criteria of the American College of Cardiology (ACC) and 200 healthy subjects (HS).

The −794 CATT5–8 MIF gene polymorphism was analyzed using a conventional polymerase chain reaction (PCR) technique.

The 6 allele was the most frequent in both groups (ACS: 54% and HS: 57%).

The most common genotypes in ACS patients and HS were 6/7 and 6/6, respectively, and a significant association was found between the 6/7 genotype and susceptibility to ACS (68% versus 47% in ACS and HS, resp., P=0.03).

We conclude that the 6/7 genotype of the MIF −794 CATT5–8 polymorphism is associated with susceptibility to ACS in a western Mexican population.