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Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia following Japanese Encephalitis Virus Infection
المؤلفون المشاركون
Chen, Huan-Chun
Jiang, Rong
Ye, Jing
Zhu, Bibo
Song, Yunfeng
Cao, Shengbo
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Japanese encephalitis virus (JEV) infection can cause central nervous system disease with irreversible neurological damage in humans and animals.
Evidence suggests that overactivation of microglia leads to greatly increased neuronal damage during JEV infection.
However, the mechanism by which JEV induces the activation of microglia remains unclear.
Toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I) can recognize double-stranded RNA, and their downstream signaling results in production of proinflammatory mediators.
In this study, we investigated the roles of TLR3 and RIG-I in the inflammatory response caused by JEV infection in the mouse microglial cell line.
JEV infection induced the expression of TLR3 and RIG-I and the activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38MAPK).
Knockdown of TLR3 and RIG-I attenuated activation of ERK, p38MAPK, activator protein 1 (AP-1), and nuclear factor κB (NF-κB).
Secretion of TNF-α, IL-6, and CCL-2, which was induced by JEV, was reduced by TLR3 and RIG-I knockdown and inhibitors of phosphorylated ERK and p38MAPK.
Furthermore, viral proliferation was increased following knockdown of TLR3 and RIG-I.
Our findings suggest that the signaling pathways of TLR3 and RIG-I play important roles in the JEV-induced inflammatory response of microglia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Rong& Ye, Jing& Zhu, Bibo& Song, Yunfeng& Chen, Huan-Chun& Cao, Shengbo. 2014. Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia following Japanese Encephalitis Virus Infection. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040981
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Rong…[et al.]. Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia following Japanese Encephalitis Virus Infection. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040981
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Rong& Ye, Jing& Zhu, Bibo& Song, Yunfeng& Chen, Huan-Chun& Cao, Shengbo. Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia following Japanese Encephalitis Virus Infection. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040981
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040981
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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