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The Effect of Combination Therapy with Rituximab and Intravenous Immunoglobulin on the Progression of Chronic Antibody Mediated Rejection in Renal Transplant Recipients
المؤلفون المشاركون
Yang, Chul Woo
An, Gun Hee
Yun, Jintak
Hong, Yu Ah
Khvan, Marina
Chung, Byung Ha
Choi, Yeong Jin
Park, Cheol Whee
Choi, Bum Soon
Kim, Yong-Soo
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The treatment for chronic active antibody-mediated rejection (CAMR) remains controversial.
We investigated the efficacy of rituximab (RTX) and intravenous immunoglobulin (IVIg) for CAMR.
Eighteen patients with CAMR were treated with RTX (375 mg/m2) and IVIg (0.4 g/kg) for 4 days.
The efficacy of RTX/IVIg combination therapy (RIT) was assessed by decline in estimated glomerular filtration rate per month (ΔeGFR) before and after RIT.
Patients were divided into responder and nonresponder groups based on decrease and no decrease in ΔeGFR, respectively, and their clinical and histological characteristics were compared.
Response rate to RIT was 66.7% (12/18), and overall ΔeGFR decreased significantly to 0.4 ± 1.7 mL·min−1·1.73 m−2 per month 6 months after RIT compared to that observed 6 months before RIT ( 1.8 ± 1.0 , P < 0.05 ).
Clinical and histological features between the 12 responders and the 6 nonresponders were not significantly different, but nonresponders had a significantly higher proteinuria levels at the time of RIT ( 2.5 ± 2.5 versus 7.0 ± 3.5 protein/creatinine (g/g), P < 0.001 ).
The effect of the RIT on ΔeGFR had dissipated in all patients by 1 year post-RIT.
Thus, RIT delayed CAMR progression, and baseline proteinuria level was a prognostic factor for response to RIT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
An, Gun Hee& Yun, Jintak& Hong, Yu Ah& Khvan, Marina& Chung, Byung Ha& Choi, Bum Soon…[et al.]. 2014. The Effect of Combination Therapy with Rituximab and Intravenous Immunoglobulin on the Progression of Chronic Antibody Mediated Rejection in Renal Transplant Recipients. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040993
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
An, Gun Hee…[et al.]. The Effect of Combination Therapy with Rituximab and Intravenous Immunoglobulin on the Progression of Chronic Antibody Mediated Rejection in Renal Transplant Recipients. Journal of Immunology Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1040993
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
An, Gun Hee& Yun, Jintak& Hong, Yu Ah& Khvan, Marina& Chung, Byung Ha& Choi, Bum Soon…[et al.]. The Effect of Combination Therapy with Rituximab and Intravenous Immunoglobulin on the Progression of Chronic Antibody Mediated Rejection in Renal Transplant Recipients. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1040993
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1040993
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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