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Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma
المؤلفون المشاركون
Zhang, Jian-Ying
Liu, Mei
Chen, Yu
Duan, Zhongping
Dai, Liping
Li, Ning
Zheng, Su-jun
Ren, Peng-fei
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide.
Although new therapeutic strategies have been continuously developed and applied to clinical treatment for HCC, the prognosis is still very poor.
Thus, early detection of HCC may enhance effective and curative management.
In this study, autoantibody responses to MDM2 protein in HCC patient’s serum were evaluated by enzyme-linked immunosorbent assay (ELISA) and part sera were evaluated by Western blotting and indirect immunofluorescence assay.
Immunohistochemistry (IHC) over tissue array slides was also performed to analyze protein expression of MDM2 in HCC and control tissues.
The prevalence of autoantibodies against MDM2 was significantly higher than that in liver cirrhosis (LC), chronic hepatitis (CH), and normal human sera (NHS).
The average titer of autoantibodies against MDM2 in HCC serum was higher compared to that in LC, CH, and NHS.
A high titer of autoantibodies against MDM2 in ELISA could be observed in the serum in 6 to 9 months before the clinical diagnosis of HCC in the serum of several HCC patients with serial bleeding samples.
Our preliminary data indicate that MDM2 and anti-MDM2 system may be a potential biomarker for early stage HCC screening and immunodiagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Mei& Zheng, Su-jun& Chen, Yu& Li, Ning& Ren, Peng-fei& Dai, Liping…[et al.]. 2014. Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1041008
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Mei…[et al.]. Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1041008
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Mei& Zheng, Su-jun& Chen, Yu& Li, Ning& Ren, Peng-fei& Dai, Liping…[et al.]. Autoantibody Response to Murine Double Minute 2 Protein in Immunodiagnosis of Hepatocellular Carcinoma. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1041008
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1041008
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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