IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN- γ Release by Autologous NK Cells
المؤلفون المشاركون
Morandi, Fabio
Airoldi, Irma
Pistoia, Vito
المصدر
Journal of Immunology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
HLA-G and HLA-E are HLA-Ib molecules with several immunoregulatory properties.
Their cell surface expression can be modulated by different cytokines.
Since IL-27 and IL-30 may either stimulate or regulate immune responses, we have here tested whether these cytokines may modulate HLA-G and -E expression and function on human monocytes.
Monocytes expressed gp130 and WSX-1, the two chains of IL27 receptor (R), and IL6R α (that serves as IL-30R, in combination with gp130).
However, only IL27R appeared to be functional, as witnessed by IL-27 driven STAT1/ STAT3 phosphorylation.
IL-27, but not IL-30, significantly upregulated HLA-E (but not HLA-G) expression on monocytes.
IFN- γ ; secretion by activated NK cells was dampened when the latter cells were cocultured with IL-27 pretreated autologous monocytes.
Such effect was not achieved using untreated or IL-30 pretreated monocytes, thus indicating that IL-27 driven HLA-E upregulation might be involved, possibly through the interaction of this molecule with CD94/NKG2A inhibitory receptor on NK cells.
In contrast, cytotoxic granules release by NK cell in response to K562 cells was unaffected in the presence of IL-27 pretreated monocytes.
In conclusion, we delineated a novel immunoregulatory function of IL-27 involving HLA-E upregulation on monocytes that might in turn indirectly impair some NK cell functions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Morandi, Fabio& Airoldi, Irma& Pistoia, Vito. 2014. IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN- γ Release by Autologous NK Cells. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1041015
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Morandi, Fabio…[et al.]. IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN- γ Release by Autologous NK Cells. Journal of Immunology Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1041015
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Morandi, Fabio& Airoldi, Irma& Pistoia, Vito. IL-27 Driven Upregulation of Surface HLA-E Expression on Monocytes Inhibits IFN- γ Release by Autologous NK Cells. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1041015
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1041015
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر