The Long-Term Fate and Toxicity of PEG-Modified Single-Walled Carbon Nanotube Isoliquiritigenin Delivery Vehicles in Rats

المؤلفون المشاركون

Han, Bo
Zhang, Mingming
Tang, Ting
Wang, Keyu
Li, Le
Chen, Wen
Zheng, Qiusheng

المصدر

Journal of Nanomaterials

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-03-16

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الكيمياء
هندسة مدنية

الملخص EN

Oxidized single-walled carbon nanotubes (o-SWNTs) was modified by covalently and noncovalently linking PEG to the o-SWNTs.

The influence of oxidation time, PEG molecular weight, and type of PEG linkage on the blood clearance time of PEG-modified single-walled carbon nanotubes (SWNTs) was investigated.

The toxicity profile of SWNTs covalently linked to PEG (c-PEG-o-SWNTs) in rats has also been determined.

The pharmacokinetics of c-PEG-o-SWNTs in rats and their distribution in vital organs were monitored by Raman spectroscopy, and the blood clearance of homogenate isoliquiritigenin (ISL) was determined by HPLC.

Photos of tissue and tissue sections were taken to evaluate the toxicity of c-PEG-o-SWNTs.

We found that SWNTs which were covalently modified with PEG and have a molecular weight of 3500 had the longest blood clearance half-lives.

However, SWNTs were toxic to the kidneys and the hearts.

The high renal clearance of long-term fate SWNTs may occur because of impaired kidney filtration function.

Therefore, we assume that while researchers study the long-term fate of SWNTs, the toxicity of SWNTs also needs to be taken into account.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Han, Bo& Zhang, Mingming& Tang, Ting& Zheng, Qiusheng& Wang, Keyu& Li, Le…[et al.]. 2014. The Long-Term Fate and Toxicity of PEG-Modified Single-Walled Carbon Nanotube Isoliquiritigenin Delivery Vehicles in Rats. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1041357

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Han, Bo…[et al.]. The Long-Term Fate and Toxicity of PEG-Modified Single-Walled Carbon Nanotube Isoliquiritigenin Delivery Vehicles in Rats. Journal of Nanomaterials No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1041357

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Han, Bo& Zhang, Mingming& Tang, Ting& Zheng, Qiusheng& Wang, Keyu& Li, Le…[et al.]. The Long-Term Fate and Toxicity of PEG-Modified Single-Walled Carbon Nanotube Isoliquiritigenin Delivery Vehicles in Rats. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1041357

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1041357