Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and In Vitro Characterization
المؤلفون المشاركون
Varshosaz, Jaleh
Mohammadi Ghalaei, Parviz
Hassanzadeh, Farshid
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The aim of the present study was preparation of hyaluronan (HA) targeted solid lipid nanoparticles (SLNs) of etoposide.
SLNs were prepared by an emulsification-solvent evaporation method and physically coated with HA.
Four variables, including the ratio of cetyl alcohol to cationic lipid, cationic lipid type (stearylamine (SA) or dodecylamine (DDA)), lipid to HA ratio, and organic to aqueous phase ratio, were studied in an irregular fraction factorial design.
Four responses, including particle size, zeta potential, drug loading, and 24-hour release efficiency percent, were measured for each formulation and then the optimization was carried out.
The percent of HA coated on the SLNs was calculated by CHN elemental analysis which was shown to be about 55.89%.
The cationic lipid type and the ratio of cetyl alcohol to cationic lipid had the highest influence on particle size and zeta potential, respectively.
The highest effects of the ratio of lipid to HA and the organic to aqueous phase ratio were on the drug loading efficiency of SLNs.
The optimized formulation of SLNs was obtained by SA, the equal proportion of cetyl alcohol and cationic lipid, the ratio of 1.5 for lipid to HA, and 10% of organic phase to aqueous phase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Varshosaz, Jaleh& Mohammadi Ghalaei, Parviz& Hassanzadeh, Farshid. 2014. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and In Vitro Characterization. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1041409
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Varshosaz, Jaleh…[et al.]. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and In Vitro Characterization. Journal of Nanomaterials No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1041409
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Varshosaz, Jaleh& Mohammadi Ghalaei, Parviz& Hassanzadeh, Farshid. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and In Vitro Characterization. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1041409
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1041409
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر