Disseminated Tumor Cells in Bone Marrow of Gastric Cancer Patients: Correlation with Tumor Hypoxia and Clinical Relevance
المؤلفون المشاركون
Bubnovskaya, Larissa
Kovelskaya, Antonina
Gumenyuk, Lilya
Ganusevich, Irina
Mamontova, Lesya
Mikhailenko, Victor
Osinsky, Dmitry
Merentsev, Sergej
Osinsky, Sergej
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
The evaluation of the clinical relevance of disseminated tumor cells (DTCs) in bone marrow (BM) of patients with gastric cancer (GC) and their association with primary tumor hypoxia.
Patients and Methods.
89 resected specimens were used.
DTCs were detected using immunocytochemistry, the level of tumor hypoxia using NMR spectroscopy, CD68, CD34, VEGF, and VEGFR-1 (Flt-1) expression using immunohistochemistry, and MMP-2 and MMP-9 activity using zymography.
Results.
DTCs were detected in 51.4% of GC patients with M0.
There was significant correlation between frequency of DTCs in BM and level of tumor hypoxia (P<0.024).
DTCs presence was accompanied with Flt-1 positivity of BM.
The correlation between DTCs and tumor VEGF expression in patients with M0 was shown (P<0.0248).
Activity of MMP-2 and MMP-9 in BM was linked with DTCs in patients with M0 (P<0.05).
Overall survival (OS) of patients with M0 and DTCs was shorter than that of patients without DTCs (patients in both groups were operated only) (P=0.0497).
Conclusion.
Appearance of DTCs correlates with hypoxia level in primary tumors.
Detection of DTCs in GC patients may be relevant indicator for adjuvant chemotherapy using.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bubnovskaya, Larissa& Kovelskaya, Antonina& Gumenyuk, Lilya& Ganusevich, Irina& Mamontova, Lesya& Mikhailenko, Victor…[et al.]. 2014. Disseminated Tumor Cells in Bone Marrow of Gastric Cancer Patients: Correlation with Tumor Hypoxia and Clinical Relevance. Journal of Oncology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042253
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bubnovskaya, Larissa…[et al.]. Disseminated Tumor Cells in Bone Marrow of Gastric Cancer Patients: Correlation with Tumor Hypoxia and Clinical Relevance. Journal of Oncology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042253
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bubnovskaya, Larissa& Kovelskaya, Antonina& Gumenyuk, Lilya& Ganusevich, Irina& Mamontova, Lesya& Mikhailenko, Victor…[et al.]. Disseminated Tumor Cells in Bone Marrow of Gastric Cancer Patients: Correlation with Tumor Hypoxia and Clinical Relevance. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042253
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042253
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر