Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer
المؤلفون المشاركون
Jacob, Omar
Murray, Nigel P.
Fuentealba, Cynthia
Reyes, Eduardo
Orellana, Nelson
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To determine if primary circulating prostate cells (CPCs) are found in all men with prostate cancer.
Methods and Patients.
A prospective study, to analyze all men with an elevated PSA between 4.0 and 10.0 ng/mL undergoing initial biopsy.
Primary CPCs were obtained by differential gel centrifugation and detected using standard immunocytochemistry using anti-PSA; positive samples underwent a second process with anti-P504S.
A malignant primary CPC was defined as PSA (+) P504S (+) and a test positive if 1 cell/4 mL was detected.
Biopsy results were registered as cancer/no-cancer, number of cores positive, and percent infiltration of the cores.
Results.
328/1123 (29.2%) of the study population had prostate cancer diagnosed on initial biopsy, and 42/328 (12.8%) were negative for primary CPCs.
CPC negative men were significantly older, and had lower PSA levels, lower Gleason scores, and fewer positive cores and with infiltration by the cancer.
38/42 (91%) of CPC negative men complied with the criteria for active surveillance in comparison with 34/286 (12%) of CPC positive men.
Conclusions.
Using primary CPC detection as a sequential test to select men with an elevated PSA for biopsy, the risk of missing clinically significant prostate cancer is minimal when the patient is primary CPC negative; less than 0.5% of all primary CPC negative men had a clinically significant prostate cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Murray, Nigel P.& Reyes, Eduardo& Fuentealba, Cynthia& Orellana, Nelson& Jacob, Omar. 2014. Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer. Journal of Oncology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042257
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Murray, Nigel P.…[et al.]. Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer. Journal of Oncology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042257
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Murray, Nigel P.& Reyes, Eduardo& Fuentealba, Cynthia& Orellana, Nelson& Jacob, Omar. Primary Circulating Prostate Cells Are Not Detected in Men with Low Grade Small Volume Prostate Cancer. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042257
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042257
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر