Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity
المؤلفون المشاركون
Wood, G. Craig
Argyropoulos, George A.
Petrick, Anthony T.
Still, Christopher D.
Gerhard, Glenn S.
Benotti, Peter
Chu, Xin
Strodel, William E.
Gabrielsen, Jon D.
Ibele, Anna
Kingsley, Christopher
DiStefano, Johanna
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
The accumulation of lipids stored as excess triglycerides in the liver (steatosis) is highly prevalent in obesity and has been associated with several clinical characteristics, but most studies have been based on relatively small sample sizes using a limited set of variables.
We sought to identify clinical factors associated with liver fat accumulation in a large cohort of patients with extreme obesity.
Methods.
We analyzed 2929 patients undergoing intraoperative liver biopsy during a primary bariatric surgery.
Univariate and multivariate regression modeling was used to identify associations with over 200 clinical variables with the presence of any fat in the liver and with moderate to severe versus mild fat accumulation.
Results.
A total of 19 data elements were associated with the presence of liver fat and 11 with severity of liver fat including ALT and AST, plasma lipid, glucose, and iron metabolism variables, several medications and laboratory measures, and sleep apnea.
The accuracy of a multiple logistic regression model for presence of liver fat was 81% and for severity of liver fat accumulation was 77%.
Conclusions.
A limited set of clinical factors can be used to model hepatic fat accumulation with moderate accuracy and may provide potential mechanistic insights in the setting of extreme obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gerhard, Glenn S.& Benotti, Peter& Wood, G. Craig& Chu, Xin& Argyropoulos, George A.& Petrick, Anthony T.…[et al.]. 2014. Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity. Journal of Obesity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1042344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gerhard, Glenn S.…[et al.]. Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity. Journal of Obesity No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1042344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gerhard, Glenn S.& Benotti, Peter& Wood, G. Craig& Chu, Xin& Argyropoulos, George A.& Petrick, Anthony T.…[et al.]. Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity. Journal of Obesity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1042344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر