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Aqueous Interleukin-6 Levels Are Superior to Vascular Endothelial Growth Factor in Predicting Therapeutic Response to Bevacizumab in Age-Related Macular Degeneration
المؤلفون المشاركون
Chalam, K. V.
Grover, Sandeep
Sambhav, Kumar
Balaiya, Sankarathi
Murthy, Ravi K.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-10
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To prospectively evaluate the effect of intravitreal bevacizumab on aqueous levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in patients with exudative age-related macular degeneration (AMD) and correlate clinical outcomes with cytokine levels.
Methods.
30 eyes of 30 patients with exudative AMD underwent intravitreal injection of bevacizumab three times at monthly intervals.
The aqueous samples prior to the 1st injection (baseline) and 3rd injection were analyzed for VEGF and IL-6 levels.
Subjects were subgrouped based upon change in the central subfield (CSF) macular thickness on SD-OCT at 8 weeks.
Group 1 included patients ( n = 14 ) with a decrease in CSF thickness greater than 10% from the baseline (improved group).
Group 2 included patients ( n = 16 ) who had a decrease in CSF thickness 10% or less (treatment-resistant).
Results.
In subgroup analysis, in both groups 1 and 2 patients, compared to aqueous VEGF, aqueous IL-6 levels showed a better correlation with CSF thickness on SD-OCT ( r = 0.72 and 0.71, resp.).
Conclusions.
Aqueous IL-6 may be an important marker of treatment response or resistance in wet macular degeneration.
Future therapeutic strategies may include targeted treatment against both VEGF and IL-6, in patients who do not respond to anti-VEGF treatment alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chalam, K. V.& Grover, Sandeep& Sambhav, Kumar& Balaiya, Sankarathi& Murthy, Ravi K.. 2014. Aqueous Interleukin-6 Levels Are Superior to Vascular Endothelial Growth Factor in Predicting Therapeutic Response to Bevacizumab in Age-Related Macular Degeneration. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042546
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chalam, K. V.…[et al.]. Aqueous Interleukin-6 Levels Are Superior to Vascular Endothelial Growth Factor in Predicting Therapeutic Response to Bevacizumab in Age-Related Macular Degeneration. Journal of Ophthalmology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042546
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chalam, K. V.& Grover, Sandeep& Sambhav, Kumar& Balaiya, Sankarathi& Murthy, Ravi K.. Aqueous Interleukin-6 Levels Are Superior to Vascular Endothelial Growth Factor in Predicting Therapeutic Response to Bevacizumab in Age-Related Macular Degeneration. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042546
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042546
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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