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Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani
المؤلفون المشاركون
Chakraborty, Sudipta
Bhar, Kaushik
Saha, Sandip
Chakrabarti, Rajarshi
Pal, Anjali
Siddhanta, Anirban
المصدر
Journal of Parasitology Research
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-12-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Visceral leishmaniasis, a vector-borne tropical disease that is threatening about 350 million people worldwide, is caused by the protozoan parasite Leishmania donovani.
Metalloids like arsenic and antimony have been used to treat diseases like leishmaniasis caused by the kinetoplastid parasites.
Arsenic (III) at a relatively higher concentration (30 μg/mL) has been shown to have antileishmanial activity, but this concentration is reported to be toxic in several experimental mammalian systems.
Nanosized metal (0) particles have been shown to be more effective than their higher oxidation state forms.
There is no information so far regarding arsenic nanoparticles (As-NPs) as an antileishmanial agent.
We have tested the antileishmanial properties of the As-NPs, developed for the first time in our laboratory.
As-NPs inhibited the in vitro growth, oxygen consumption, infectivity, and intramacrophage proliferation of L.
donovani parasites at a concentration which is about several fold lower than that of As (III).
Moreover, this antileishmanial activity has comparatively less cytotoxic effect on the mouse macrophage cell line.
It is evident from our findings that As-NPs have more potential than As (III) to be used as an antileishmanial agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chakraborty, Sudipta& Bhar, Kaushik& Saha, Sandip& Chakrabarti, Rajarshi& Pal, Anjali& Siddhanta, Anirban. 2014. Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani. Journal of Parasitology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1042780
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chakraborty, Sudipta…[et al.]. Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani. Journal of Parasitology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1042780
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chakraborty, Sudipta& Bhar, Kaushik& Saha, Sandip& Chakrabarti, Rajarshi& Pal, Anjali& Siddhanta, Anirban. Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovani. Journal of Parasitology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1042780
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1042780
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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