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Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane
المؤلفون المشاركون
Kim, Seongho
Rosner, Karli
Mehregan, Darius R.
Kirou, Evangelia
Campbell, Michelle
Frieder, Jillian
Lawrence, Kelsey
Haynes, Brittany
Shekhar, Malathy P. V.
Abrams, Judith
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We have previously demonstrated that Rad6 and β-catenin enhance each other's expression through a positive feedback loop to promote breast cancer development/progression.
While β-catenin has been implicated in melanoma pathogenesis, Rad6 function has not been investigated.
Here, we examined the relationship between Rad6 and β-catenin in melanoma development and progression.
Eighty-eight cutaneous tumors, 30 nevi, 29 primary melanoma, and 29 metastatic melanomas, were immunostained with anti-β-catenin and anti-Rad6 antibodies.
Strong expression of Rad6 was observed in only 27% of nevi as compared to 100% of primary and 96% of metastatic melanomas.
β-Catenin was strongly expressed in 97% of primary and 93% of metastatic melanomas, and unlike Rad6, in 93% of nevi.
None of the tumors expressed nuclear β-catenin.
β-Catenin was exclusively localized on the cell membrane of 55% of primary, 62% of metastatic melanomas, and only 10% of nevi.
Cytoplasmic β-catenin was detected in 90% of nevi, 17% of primary, and 8% of metastatic melanoma, whereas 28% of primary and 30% of metastatic melanomas exhibited β-catenin at both locations.
These data suggest that melanoma development and progression are associated with Rad6 upregulation and membranous redistribution of β-catenin and that β-catenin and Rad6 play independent roles in melanoma development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rosner, Karli& Mehregan, Darius R.& Kirou, Evangelia& Abrams, Judith& Kim, Seongho& Campbell, Michelle…[et al.]. 2014. Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane. Journal of Skin Cancer،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043028
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rosner, Karli…[et al.]. Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane. Journal of Skin Cancer No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043028
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rosner, Karli& Mehregan, Darius R.& Kirou, Evangelia& Abrams, Judith& Kim, Seongho& Campbell, Michelle…[et al.]. Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane. Journal of Skin Cancer. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043028
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043028
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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