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Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients
المؤلفون المشاركون
Pruetz, Barbara L.
Geddes, Timothy J.
Thibodeau, Bryan J.
Masterson, Loren
Fortier, Laura E.
Malhotra, Rajwant
Keidan, Richard
Wilson, George D.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Due to the rarity of Merkel cell carcinoma (MCC), prospective clinical trials have not been practical.
This study aimed to identify biomarkers with prognostic significance.
While sixty-two patients were identified who were treated for MCC at our institution, only seventeen patients had adequate formalin-fixed paraffin-embedded archival tissue and followup to be included in the study.
Patients were stratified into good, moderate, or poor prognosis.
Laser capture microdissection was used to isolate tumor cells for subsequent RNA isolation and gene expression analysis with Affymetrix GeneChip Human Exon 1.0 ST arrays.
Among the 191 genes demonstrating significant differential expression between prognostic groups, keratin 20 and neurofilament protein have previously been identified in studies of MCC and were significantly upregulated in tumors from patients with a poor prognosis.
Immunohistochemistry further established that keratin 20 was overexpressed in the poor prognosis tumors.
In addition, novel genes of interest such as phospholipase A2 group X, kinesin family member 3A, tumor protein D52, mucin 1, and KIT were upregulated in specimens from patients with poor prognosis.
Our pilot study identified several gene expression differences which could be used in the future as prognostic biomarkers in MCC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Masterson, Loren& Thibodeau, Bryan J.& Fortier, Laura E.& Geddes, Timothy J.& Pruetz, Barbara L.& Malhotra, Rajwant…[et al.]. 2014. Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients. Journal of Skin Cancer،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043030
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Masterson, Loren…[et al.]. Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients. Journal of Skin Cancer No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043030
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Masterson, Loren& Thibodeau, Bryan J.& Fortier, Laura E.& Geddes, Timothy J.& Pruetz, Barbara L.& Malhotra, Rajwant…[et al.]. Gene Expression Differences Predict Treatment Outcome of Merkel Cell Carcinoma Patients. Journal of Skin Cancer. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043030
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043030
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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