Determination of Muscone in Rats Plasma following Oral Administration of Artificial Musk: Using of Combined Headspace Gas Chromatography-Mass Spectrometry
المؤلفون المشاركون
Wu, Qibiao
Li, Haitao
Leng, Yujing
Deng, Haishan
Cheng, Haibo
Shen, Weixing
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
To develop an analytical method for determination of plasma concentrations of muscone in rats following oral administration of artificial musk, with the aim of investigating the pharmacokinetic profile of artificial musk.
Plasma samples were pretreated with acetonitrile to precipitate proteins.
Headspace injection coupled with gas chromatography-mass spectrometry was used for quantitative analysis of muscone concentrations.
A strong linear relationship was obtained for plasma muscone concentrations ranging from 75.6 to 7560 ng·mL−1 R2=0.9998, with the minimum detectable concentration being 25 ng·mL−1.
The within-day and interday precision for determination of three different concentrations of muscone were favorable (RSD < 25%).
The average absolute recovery ranged from 83.7 to 88.6%, with an average relative recovery of 100.5 to 109.8%.
The method described was characterized by stability and reliability, and in the present study showed significant specificity and high sensitivity.
This method would be applicable to the analysis of plasma concentrations of muscone in preclinical contexts, where artificial musk is used.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Qibiao& Li, Haitao& Leng, Yujing& Deng, Haishan& Cheng, Haibo& Shen, Weixing. 2014. Determination of Muscone in Rats Plasma following Oral Administration of Artificial Musk: Using of Combined Headspace Gas Chromatography-Mass Spectrometry. Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043149
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Qibiao…[et al.]. Determination of Muscone in Rats Plasma following Oral Administration of Artificial Musk: Using of Combined Headspace Gas Chromatography-Mass Spectrometry. Journal of Spectroscopy No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043149
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Qibiao& Li, Haitao& Leng, Yujing& Deng, Haishan& Cheng, Haibo& Shen, Weixing. Determination of Muscone in Rats Plasma following Oral Administration of Artificial Musk: Using of Combined Headspace Gas Chromatography-Mass Spectrometry. Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043149
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043149
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر