![](/images/graphics-bg.png)
Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats
المؤلفون المشاركون
Adedara, Isaac A.
Abolaji, Amos O.
Odion, Blessing E.
Okwudi, Isioma J.
Omoloja, Abiola A.
Farombi, Ebenezer O.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-10-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
2,5-Hexanedione (2,5-HD) is the toxic metabolite of n-hexane which is widely used as solvent in numerous industries.
The present study elucidated the precise mechanism of 2,5-HD in hepatorenal toxicity by determining the involvement of oxidative stress in rats.
Adult male Wistar rats were exposed to 0, 0.25, 0.5, and 1% 2,5-HD in drinking water for 21 days.
Exposure to 2,5-HD caused liver and kidney atrophy evidenced by significant elevation in serum aminotransferases, alkaline phosphatase, albumin, bilirubin, urea, creatinine, and electrolytes levels compared with control.
The marked dose-dependent increase in total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) was accompanied with significant decrease in high-density lipoprotein (HDL) levels in 2,5-HD-exposed animals when compared with the control.
Administration of 2,5-HD significantly diminished glutathione (GSH) level but increased the activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione-S-transferase (GST) concomitantly with marked elevation in hydrogen peroxide (H2O2) and malondialdehyde (MDA) levels in liver and kidney of the treated groups compared with control.
These findings suggest that undue exposure to 2,5-HD at environmentally relevant levels may impair liver and kidney functions through induction of oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adedara, Isaac A.& Abolaji, Amos O.& Odion, Blessing E.& Okwudi, Isioma J.& Omoloja, Abiola A.& Farombi, Ebenezer O.. 2014. Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043180
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adedara, Isaac A.…[et al.]. Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats. Journal of Toxicology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043180
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adedara, Isaac A.& Abolaji, Amos O.& Odion, Blessing E.& Okwudi, Isioma J.& Omoloja, Abiola A.& Farombi, Ebenezer O.. Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043180
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043180
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)