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In Vitro Reporter Assays for Screening of Chemicals That Disrupt Androgen Signaling
المؤلفون المشاركون
Bagchi Bhattacharjee, Gargi
Paul Khurana, S. M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-11-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Endocrine disruptive chemicals (EDCs) modulate hormone signaling and cause developmental and reproductive anomalies.
Today, there is a global concern regarding endocrine disruption effects, particularly those mediated by the androgen receptor (AR).
Androgen or male hormones are critical for the development and maintenance of male characteristics and numerous EDCs exist in the environment with the potential to disrupt androgen action.
The threat is more during critical developmental windows when there is increased sensitivity to these compounds.
Timely screening and detection of the EDCs is essential to minimize deleterious effects produced by these toxic chemicals.
As a first line of screening, in vitro transcription assays are very useful due to their speed, convenience, and cost effectiveness.
In this paper, recent in vitro reporter assays for detecting androgenic or antiandrogenic activity of EDCs have been reviewed.
Two important cell systems used for this purpose, namely, the mammalian or yeast cell systems, have been discussed.
Use of reporter genes such as bacterial luciferase (lux) and green fluorescent protein (gfp) has significantly improved speed and sensitivity of detection.
Also, many of the current reporter assay systems can be used in a high throughput format allowing speedy evaluation of multiple potential EDCs at a lower price.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bagchi Bhattacharjee, Gargi& Paul Khurana, S. M.. 2014. In Vitro Reporter Assays for Screening of Chemicals That Disrupt Androgen Signaling. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bagchi Bhattacharjee, Gargi& Paul Khurana, S. M.. In Vitro Reporter Assays for Screening of Chemicals That Disrupt Androgen Signaling. Journal of Toxicology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bagchi Bhattacharjee, Gargi& Paul Khurana, S. M.. In Vitro Reporter Assays for Screening of Chemicals That Disrupt Androgen Signaling. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1043208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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